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High-performance, polymer-based direct cellular interfaces for electrical stimulation and recording

Title
High-performance, polymer-based direct cellular interfaces for electrical stimulation and recording
Authors
Kim, Seong MinKim, Na RaKim, Young SeokBaek, Min SeoYoo, Min SuKim, Dong YoonLee, Won JuneKang, Dong HeeKim, SoheeLee, Kwang HeeYoon, Myung Han
DGIST Authors
Kim, Sohee
Issue Date
2018-04
Citation
NPG Asia Materials, 10(4), 255-265
Type
Article
Article Type
Article
Keywords
Economic and social effectsElectrophysiologyInterfaces (materials)MicroelectrodesPlastic bottlesBio-electronic interfaceCultured cardiomyocytesElectrical stimulationsElectrochemical activitiesMicroelectrode arrayPoly-3 ,4-ethylenedioxythiophenePolyethylene terephthalates (PET)Polystyrene sulfonateConducting polymers
ISSN
1884-4049
Abstract
Due to the trade-off between their electrical/electrochemical performance and underwater stability, realizing polymer-based, high-performance direct cellular interfaces for electrical stimulation and recording has been very challenging. Herein, we developed transparent and conductive direct cellular interfaces based on a water-stable, high-performance poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) film via solvent-assisted crystallization. The crystallized PEDOT:PSS on a polyethylene terephthalate (PET) substrate exhibited excellent electrical/electrochemical/optical characteristics, long-term underwater stability without film dissolution/delamination, and good viability for primarily cultured cardiomyocytes and neurons over several weeks. Furthermore, the highly crystallized, nanofibrillar PEDOT:PSS networks enabled dramatically enlarged surface areas and electrochemical activities, which were successfully employed to modulate cardiomyocyte beating via direct electrical stimulation. Finally, the high-performance PEDOT:PSS layer was seamlessly incorporated into transparent microelectrode arrays for efficient, real-time recording of cardiomyocyte action potentials with a high signal fidelity. All these results demonstrate the strong potential of crystallized PEDOT:PSS as a crucial component for a variety of versatile bioelectronic interfaces. [Figure not available: see fulltext.] © 2018 The Author(s)
URI
http://hdl.handle.net/20.500.11750/6243
DOI
10.1038/s41427-018-0014-9
Publisher
Nature Publishing Group
Related Researcher
  • Author Kim, Sohee Neural Interfaces & MicroSystems Lab
  • Research Interests Neural interface; Brain interface; Bio MEMS; Soft MEMS; Stretchable electronics; Zebrafish electrophysiology
Files:
Collection:
Department of Robotics EngineeringNeural Interfaces & MicroSystems Lab1. Journal Articles


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