Cited 7 time in webofscience Cited 8 time in scopus

Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response

Title
Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response
Authors
Li, YanKim, Ryun HeeCho, Yi SulSong, Woo SeokKim, Do YounKim, Kyung DeokRoh, Junyeop DanielChung, ChangukPark, Han WoolYang, EstherKim, Soo JeongKo, JaewonKim, HyunKim, Myoung HwanBae, Yong ChulKim, Eun Joon
DGIST Authors
Ko, Jaewon
Issue Date
2018-06
Citation
Journal of Neuroscience, 38(26), 5872-5887
Type
Article
Article Type
Article
Keywords
excitatory synaptic functionGABAergic neuronsinhibitory synapsesLrfn2NMDA receptorsocial communicationADHESION-LIKE MOLECULESULTRASONIC VOCALIZATIONSNMDA RECEPTORMOUSE MODELSSALM/LRFN FAMILYLAR-RPTPSORGANIZERSDISORDERSCOMPLEXESPROTEINS
ISSN
0270-6474
Abstract
SALM1 (SALM (synaptic adhesion-like molecule), also known as LRFN2 (leucine rich repeat and fibronectin type III domain containing), is a postsynaptic density (PSD)-95-interacting synaptic adhesion molecule implicated in the regulation of NMDA receptor (NMDAR) clustering largely based on in vitro data, although its in vivo functions remain unclear. Here, we found that mice lacking SALM1/LRFN2 (Lrfn2-/- mice) show a normal density of excitatory synapses but altered excitatory synaptic function, including enhanced NMDAR-dependent synaptic transmission but suppressed NMDAR-dependent synaptic plasticity in the hippocampal CA1 region. Unexpectedly, SALM1 expression was detected in both glutamatergic and GABAergic neurons and Lrfn2-/- CA1 pyramidal neurons showed decreases in the density of inhibitory synapses and the frequency of spontaneous inhibitory synaptic transmission. Behaviorally, ultrasonic vocalization was suppressed in Lrfn2-/- pups separated from their mothers and acoustic startle was enhanced, but locomotion, anxiety-like behavior, social interaction, repetitive behaviors, and learning and memory were largely normal in adult male Lrfn2-/- mice. These results suggest that SALM1/LRFN2 regulates excitatory synapse function, inhibitory synapse development, and social communication and startle behaviors in mice. © 2018 the authors.
URI
http://hdl.handle.net/20.500.11750/9047
DOI
10.1523/JNEUROSCI.3321-17.2018
Publisher
Society for Neuroscience
Related Researcher
  • Author Ko, Jaewon Laboratory of Synapse Formation and Function
  • Research Interests Synapse Formation and Function; Neural Circuits; 뇌질환; animal model
Files:
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Collection:
Department of Brain and Cognitive SciencesLaboratory of Synapse Formation and Function1. Journal Articles


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