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Circadian control of ORE1 by PRR9 positively regulates leaf senescence in Arabidopsis
- Circadian control of ORE1 by PRR9 positively regulates leaf senescence in Arabidopsis
- Kim, Hyunmin; Kim, Hyo Jung; Quy, Thi Vu; Jung, Sukjoon; McClung, C. Robertson; Hong, Sunghyun; Nam, Hong Gil
- DGIST Authors
- Nam, Hong Gil
- Issue Date
- Proceedings of the National Academy of Sciences of the United States of America, 115(33), 8448-8453
- Article Type
- Author Keywords
- circadian clock; leaf senescence; PRR9; ORE1; miR164
- LIFE-SPAN; CLOCK; TRANSCRIPTION; GENES; MECHANISMS; EXPRESSION; MICRORNAS; RHYTHMS; LEAVES; DEATH
- The circadian clock coordinates the daily cyclic rhythm of numerous biological processes by regulating a large portion of the transcriptome. In animals, the circadian clock is involved in aging and senescence, and circadian disruption by mutations in clock genes frequently accelerates aging. Conversely, aging alters circadian rhythmicity, which causes age-associated physiological alterations. However, interactions between the circadian clock and aging have been rarely studied in plants. Here, we investigated potential roles for the circadian clock in the regulation of leaf senescence in plants. Members of the evening complex in Arabidopsis circadian clock, EARLY FLOWERING 3 (ELF3), EARLY FLOWERING 4 (ELF4), and LUX ARRHYTHMO (LUX), as well as the morning component PSEUDO-RESPONSE REGULATOR 9 (PRR9), affect both age-dependent and dark-induced leaf senescence. The circadian clock regulates the expression of several senescence-related transcription factors. In particular, PRR9 binds directly to the promoter of the positive aging regulator ORESARA1 (ORE1) gene to promote its expression. PRR9 also represses miR164, a posttranscriptional repressor of ORE1. Consistently, genetic analysis revealed that delayed leaf senescence of a prr9 mutant was rescued by ORE1 overexpression. Thus, PRR9, a core circadian component, is a key regulator of leaf senescence via positive regulation of ORE1 through a feed-forward pathway involving posttranscriptional regulation by miR164 and direct transcriptional regulation. Our results indicate that, in plants, the circadian clock and leaf senescence are intimately interwoven as are the clock and aging in animals.
- National Academy of Sciences
- Related Researcher
Nam, Hong Gil
CBRG(Complex Biology Research Group)
Plant Aging and Life History; Systems Biology; Complexbiology; Comparative Aging Research
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- Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
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