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A highly sensitive and selective biosensor based on nitrogen-doped graphene for non-enzymatic detection of uric acid and dopamine at biological pH value
- A highly sensitive and selective biosensor based on nitrogen-doped graphene for non-enzymatic detection of uric acid and dopamine at biological pH value
- Foroughi, Faranak; Rahsepar, Mansour; Kim, Hasuck
- Issue Date
- Journal of Electroanalytical Chemistry, 827, 34-41
- Article Type
- Graphene; N-doping; Cyclic voltammetry; Dopamine biosensor; Uric acid biosensor; Microwave synthesis; Cyclic voltammetry; Dopamine biosensor; Graphene; Microwave synthesis; N-doping; Uric acid biosensor; Amines; Biosensors; Chronoamperometry; Cyclic voltammetry; Doping (additives); Graphite electrodes; Microwave irradiation; Neurophysiology; Nitrogen; Organic acids; X ray photoelectron spectroscopy; Linear concentration; Microwave synthesis; N-Doping; Nitrogen doped graphene; Non-enzymatic detection; Ultra-high-sensitivity; Uric acid biosensors; Voltammetry measurements; Graphene
- Few layered graphene nanosheets were successfully doped with nitrogen through microwave irradiation and thoroughly characterized by using electron microscopy, Raman spectroscopy and X-ray photoelectron spectroscopy. The electrochemical efficiency of N-doped graphene toward enzyme-free detection of uric acid (UA) and dopamine (DA) at neutral pH (7.4) was studied by chronoamperometry and cyclic voltammetry measurements. At working potential of +0.3 V (vs. Ag/AgCl), N-doped graphene electrode revealed ultra-high sensitivity of 2.06 mA mM−1 cm−2 and low limit of detection (LOD) of 0.13 μM within a concentration range of 0 to 0.6 mM for UA detection. Also, at very higher potential of +1.8 V (vs. Ag/AgCl), N-doped graphene sensor exhibited a highly selective response toward DA with very low LOD of 4.5 nM and high sensitivity of 7.63 mA mM−1 cm−2 in a broad linear concentration range from 0.1 to 100 μM. Furthermore, the performance of UA and DA sensors in the real blood sample was satisfactory. © 2018
- Elsevier B.V.
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