Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Park, Youngchan | - |
dc.contributor.author | Shin, Sangwon | - |
dc.contributor.author | Jin, Hyeonggyu | - |
dc.contributor.author | Park, Jiseong | - |
dc.contributor.author | Hong, Yeonki | - |
dc.contributor.author | Choi, Jaemin | - |
dc.contributor.author | Jung, Byunghyuck | - |
dc.contributor.author | Song, Hyunjoon | - |
dc.contributor.author | Seo, Dae Ha | - |
dc.date.accessioned | 2018-12-05T07:53:02Z | - |
dc.date.available | 2018-12-05T07:53:02Z | - |
dc.date.created | 2018-11-26 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/9449 | - |
dc.description.abstract | Monitoring the dynamics of proteins in live cells on appropriate spatiotemporal scales may provide key information regarding long-standing questions in molecular and cellular regulatory mechanisms. However, tools capable of imaging the conformational changes over time have been elusive. Here, we present a single-molecule stroboscopic imaging probes by developing gyroscopic plasmonic nanoparticles, allowing for replication of protein-protein interactions and the conformational dynamics based on rotational and lateral velocities. This study fundamentally monitors the rotational motion of a membrane protein, epidermal growth factor receptor (EGFR), to decipher undiscovered structural dynamics in live cells without any molecular perturbations. This method offers a strategy to visualize assemblies and conformational changes, and provides unique insights into the mechanism underlying the molecular dynamics for receptors. © 2018 American Chemical Society. | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.title | Single-Molecule Rotation for EGFR Conformational Dynamics in Live Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/jacs.8b09037 | - |
dc.identifier.scopusid | 2-s2.0-85056406353 | - |
dc.identifier.bibliographicCitation | Journal of the American Chemical Society, v.140, no.45, pp.15161 - 15165 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordPlus | ENERGY-TRANSFER | - |
dc.subject.keywordPlus | DIMERIZATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | MOBILITY | - |
dc.subject.keywordPlus | MOTION | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | GOLD | - |
dc.citation.endPage | 15165 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 15161 | - |
dc.citation.title | Journal of the American Chemical Society | - |
dc.citation.volume | 140 | - |
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