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Genomics: New light on alzheimer’s disease research

Title
Genomics: New light on alzheimer’s disease research
Authors
Jung, Yeong JuKim, Yoon HaBhalla, MridulaLee, Sung-BaeSeo, Jinsoo
DGIST Authors
Lee, Sung-BaeSeo, Jinsoo
Issue Date
2018-12
Citation
International Journal of Molecular Sciences, 19(12)
Type
Article
Article Type
Review
Author Keyword
Genetic risk factors; Genomics; GWAS; Aging; Epigenetic modification; Alzheimer’s disease
ISSN
1422-0067
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that represents a major cause of death in many countries. AD is characterized by profound memory loss, disruptions in thinking and reasoning, and changes in personality and behavior followed by malfunctions in various bodily systems. Although AD was first identified over 100 years ago, and tremendous efforts have been made to cure the disease, the precise mechanisms underlying the onset of AD remain unclear. The recent development of next-generation sequencing tools and bioinformatics has enabled us to investigate the role of genetics in the pathogenesis of AD. In this review, we discuss novel discoveries in this area, including the results of genome-wide association studies (GWAS) that have implicated a number of novel genes as risk factors, as well as the identification of epigenetic regulators strongly associated with the onset and progression of AD. We also review how genetic risk factors may interact with age-associated, progressive decreases in cognitive function in patients with AD. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/9504
DOI
10.3390/ijms19123771
Publisher
MDPI AG
Related Researcher
  • Author Lee, Sung-Bae SB LAB(Lab of Neurodegenerative diseases and Aging)
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
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Collection:
Department of Brain and Cognitive SciencesSB LAB(Lab of Neurodegenerative diseases and Aging)1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Aging Brain1. Journal Articles


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