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Decrease of Protease-Resistant PrPSc Level in ScN2a Cells by Polyornithine and Polyhistidine

Title
Decrease of Protease-Resistant PrPSc Level in ScN2a Cells by Polyornithine and Polyhistidine
Authors
Waqas, MuhammadHuyen Trang TrinhLee, SungeunKim, Dae-HwanLee, Sang YeolChoe, Kevin K.Ryou, Chongsuk
Issue Date
2018-12
Citation
Journal of Microbiology and Biotechnology, 28(12), 2141-2144
Type
Article
Article Type
Article
ISSN
1017-7825
Abstract
Based on previous studies reporting the anti-prion activity of poly-L-lysine and poly-L-arginine, we investigated cationic poly-L-ornithine (PLO), poly-L-histidine (PLH), anionic poly-L-glutamic acid (PLE) and uncharged poly-L-threonine (PLT) in cultured cells chronically infected by prions to determine their anti-prion efficacy. While PLE and PLT did not alter the level of PrPSc, PLO and PLH exhibited potent PrPSc inhibition in ScN2a cells. These results suggest that the anti-prion activity of poly-basic amino acids is correlated with the cationicity of their functional groups. Comparison of anti-prion activity of PLO and PLH proposes that the anti-prion activity of poly-basic amino acids is associated with their acidic cellular compartments. © 2018 by The Korean Society for Microbiology and Biotechnology.
URI
http://hdl.handle.net/20.500.11750/9548
DOI
10.4014/jmb.1807.07045
Publisher
한국미생물·생명공학회
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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