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DC Field Value Language Waqas, Muhammad ko Huyen Trang Trinh ko Lee, Sungeun ko Kim, Dae-Hwan ko Lee, Sang Yeol ko Choe, Kevin K. ko Ryou, Chongsuk ko 2019-01-27T13:54:03Z - 2019-01-27T13:54:03Z - 2019-01-17 - 2018-12 -
dc.identifier.citation Journal of Microbiology and Biotechnology, v.28, no.12, pp.2141 - 2144 -
dc.identifier.issn 1017-7825 -
dc.identifier.uri -
dc.description.abstract Based on previous studies reporting the anti-prion activity of poly-L-lysine and poly-L-arginine, we investigated cationic poly-L-ornithine (PLO), poly-L-histidine (PLH), anionic poly-L-glutamic acid (PLE) and uncharged poly-L-threonine (PLT) in cultured cells chronically infected by prions to determine their anti-prion efficacy. While PLE and PLT did not alter the level of PrPSc, PLO and PLH exhibited potent PrPSc inhibition in ScN2a cells. These results suggest that the anti-prion activity of poly-basic amino acids is correlated with the cationicity of their functional groups. Comparison of anti-prion activity of PLO and PLH proposes that the anti-prion activity of poly-basic amino acids is associated with their acidic cellular compartments. © 2018 by The Korean Society for Microbiology and Biotechnology. -
dc.language English -
dc.publisher 한국미생물·생명공학회 -
dc.title Decrease of Protease-Resistant PrPSc Level in ScN2a Cells by Polyornithine and Polyhistidine -
dc.type Article -
dc.identifier.doi 10.4014/jmb.1807.07045 -
dc.identifier.wosid 000454507700020 -
dc.identifier.scopusid 2-s2.0-85059304127 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.identifier.kciid ART002424558 -
dc.contributor.nonIdAuthor Waqas, Muhammad -
dc.contributor.nonIdAuthor Huyen Trang Trinh -
dc.contributor.nonIdAuthor Lee, Sungeun -
dc.contributor.nonIdAuthor Lee, Sang Yeol -
dc.contributor.nonIdAuthor Choe, Kevin K. -
dc.contributor.nonIdAuthor Ryou, Chongsuk -
dc.identifier.citationVolume 28 -
dc.identifier.citationNumber 12 -
dc.identifier.citationStartPage 2141 -
dc.identifier.citationEndPage 2144 -
dc.identifier.citationTitle Journal of Microbiology and Biotechnology -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
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