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Small-chain fatty acid activates astrocytic odorant receptor Olfr920

Title
Small-chain fatty acid activates astrocytic odorant receptor Olfr920
Authors
Cho, Tae HoLee, ChaeEunLee, NaHyeHong, Yu RiKoo, JaeHyung
DGIST Authors
Koo, JaeHyung
Issue Date
2019-03
Citation
Biochemical and Biophysical Research Communications, 510(3), 383-387
Type
Article
Article Type
Article
Author Keyword
Astrocyte; Isobutyric acid; Metabolite; Odorant receptor; Olfr920; Short-chain fatty acids
Keyword
OLFACTORY RECEPTORS; GUT MICROBIOTA; EXPRESSION; CELLS; DYSREGULATION; SECRETION; DATABASE; FAMILY
ISSN
0006-291X
Abstract
Odorant receptors are the largest subfamily of G protein-coupled receptors and were recently suggested to play critical roles in nonolfactory tissues. However, the expression and function of odorant receptors in astrocytes, the most abundant cells in the brain, are not well known. We demonstrate that Olfr920 is highly expressed and propose that it functions as a short-chain fatty acid sensor in primary cortical astrocytes. The short-chain fatty acid isobutyric acid (IBA) was identified via a luciferase assay as an Olfr920 ligand. We show that IBA activates the Gs protein-adenylyl cyclase-cAMP pathway via Olfr920 in primary cortical astrocytes by using cAMP and knockdown analyses. In addition, IBA reduces lipopolysaccharide-induced glial fibrillary acidic protein expression in reactive astrocytes. These results suggest that astrocytic Olfr920 is a potential novel target for increased reactive astrocytes. © 2019
URI
http://hdl.handle.net/20.500.11750/9600
DOI
10.1016/j.bbrc.2019.01.106
Publisher
Academic Press
Related Researcher
  • Author Koo, JaeHyung Molecular & Cellular Smell Biology Lab
  • Research Interests Neurotranslation and chemosensation; 화학감각신경(후각, 미각) 및 이소성후각수용체 연구와 응용
Files:
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Collection:
Department of Brain and Cognitive SciencesMolecular & Cellular Smell Biology Lab1. Journal Articles


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