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Small-chain fatty acid activates astrocytic odorant receptor Olfr920

Title
Small-chain fatty acid activates astrocytic odorant receptor Olfr920
Author(s)
Cho, Tae HoLee, ChaeEunLee, NaHyeHong, Yu RiKoo, JaeHyung
DGIST Authors
Koo, JaeHyung
Issued Date
2019-03
Type
Article
Article Type
Article
Author Keywords
AstrocyteIsobutyric acidMetaboliteOdorant receptorOlfr920Short-chain fatty acids
Keywords
OLFACTORY RECEPTORSGUT MICROBIOTAEXPRESSIONCELLSDYSREGULATIONSECRETIONDATABASEFAMILY
ISSN
0006-291X
Abstract
Odorant receptors are the largest subfamily of G protein-coupled receptors and were recently suggested to play critical roles in nonolfactory tissues. However, the expression and function of odorant receptors in astrocytes, the most abundant cells in the brain, are not well known. We demonstrate that Olfr920 is highly expressed and propose that it functions as a short-chain fatty acid sensor in primary cortical astrocytes. The short-chain fatty acid isobutyric acid (IBA) was identified via a luciferase assay as an Olfr920 ligand. We show that IBA activates the Gs protein-adenylyl cyclase-cAMP pathway via Olfr920 in primary cortical astrocytes by using cAMP and knockdown analyses. In addition, IBA reduces lipopolysaccharide-induced glial fibrillary acidic protein expression in reactive astrocytes. These results suggest that astrocytic Olfr920 is a potential novel target for increased reactive astrocytes. © 2019
URI
http://hdl.handle.net/20.500.11750/9600
DOI
10.1016/j.bbrc.2019.01.106
Publisher
Academic Press
Related Researcher
  • 구재형 Koo, JaeHyung 뉴바이올로지학과
  • Research Interests 장내미생물/감염균 유래 대사체를 통한 신경염증; 알츠하이머병; 우울증; 당뇨/비만; 대사체/수용체 상호작용에 의한 대사연구
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Department of New Biology Brain-Immune Axis Laboratory 1. Journal Articles

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