Cited 2 time in webofscience Cited 3 time in scopus

Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans

Title
Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans
Authors
Park, JisooChoi, WoochanDar, Abdul RoufButcher, Rebecca A.Kim, Kyuhyung
DGIST Authors
Kim, Kyuhyung
Issue Date
2019-01
Citation
Molecules and Cells, 42(1), 28-35
Type
Article
Article Type
Article
Author Keywords
chemoreceptorgene expressionneuropeptide signalingpheromoneplasticity
Keywords
CAENORHABDITIS-ELEGANSODORANT RECEPTORSDAUER PHEROMONEEXPERIENCERESPONSESSEX
ISSN
1016-8478
Abstract
Animals need to be able to alter their developmental and behavioral programs in response to changing environmental conditions. This developmental and behavioral plasticity is mainly mediated by changes in gene expression. The knowledge of the mechanisms by which environmental signals are transduced and integrated to modulate changes in sensory gene expression is limited. Exposure to ascaroside pheromone has been reported to alter the expression of a subset of putative G protein-coupled chemosensory receptor genes in the ASI chemosensory neurons of C. elegans (Kim et al., 2009; Nolan et al., 2002; Peckol et al., 1999). Here we show that ascaroside pheromone reversibly represses expression of the str-3 chemoreceptor gene in the ASI neurons. Repression of str-3 expression can be initiated only at the L1 stage, but expression is restored upon removal of ascarosides at any developmental stage. Pheromone receptors including SRBC-64/66 and SRG-36/37 are required for str-3 repression. Moreover, pheromone-mediated str-3 repression is mediated by FLP-18 neuropeptide signaling via the NPR-1 neuropeptide receptor. These results suggest that environmental signals regulate chemosensory gene expression together with internal neuropeptide signals which, in turn, modulate behavior.
URI
http://hdl.handle.net/20.500.11750/9610
DOI
10.14348/molcells.2018.0380
Publisher
한국분자세포생물학회
Related Researcher
  • Author Kim, Kyuhyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests Neurobehavior; Neural Circuit; Neurodevelopment; 신경회로; 신경행동; 신경발생; 신경유전학
Files:
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Collection:
Department of Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles


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