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Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy
- Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy
- Kim, Evgenii; Anguluan, Eloise; Youn, Sangyeon; Kim, Jihun; Hwang, Jae Youn; Kim, Jae Gwan
- DGIST Authors
- Hwang, Jae Youn
- Issue Date
- BMC Neuroscience, 20(1)
- Article Type
- Author Keywords
- Cerebral hemodynamics; Near-infrared spectroscopy; Ultrasound brain stimulation
- POSTSTIMULUS UNDERSHOOT; BRAIN-INJURY; NEUROSTIMULATION; NEUROMODULATION; OXYGENATION; SIGNAL; EEG
- Background: Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still unclear, and further investigation is needed. The present study proposes to use near-infrared spectroscopy (NIRS) to observe cerebral hemodynamic change caused by tFUS in a noninvasive manner. Results: The results show a transient increase of oxyhemoglobin and decrease of deoxyhemoglobin concentration in the mouse model induced by ultrasound stimulation of the somatosensory cortex with a frequency of 8 MHz but not in sham. In addition, the amplitude of hemodynamics change can be related to the peak intensity of the acoustic wave. Conclusion: High frequency 8 MHz ultrasound was shown to induce hemodynamic changes measured using NIRS through the intact mouse head. The implementation of NIRS offers the possibility of investigating brain response noninvasively for different tFUS parameters through cerebral hemodynamic change. © 2019 The Author(s).
- BioMed Central Ltd.
- Related Researcher
Hwang, Jae Youn
MBIS(Multimodal Biomedical Imaging and System) Laboratory
Multimodal Imaging; High-Frequency Ultrasound Microbeam; Ultrasound Imaging and Analysis; 스마트 헬스케어; Biomedical optical system
- Department of Information and Communication EngineeringMBIS(Multimodal Biomedical Imaging and System) Laboratory1. Journal Articles
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