Cited 3 time in webofscience Cited 2 time in scopus

Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy

Title
Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy
Authors
Kim, EvgeniiAnguluan, EloiseYoun, SangyeonKim, JihunHwang, Jae YounKim, Jae Gwan
DGIST Authors
Hwang, Jae Youn
Issue Date
2019-03
Citation
BMC Neuroscience, 20(1)
Type
Article
Article Type
Article
Author Keywords
Cerebral hemodynamicsNear-infrared spectroscopyUltrasound brain stimulation
Keywords
POSTSTIMULUS UNDERSHOOTBRAIN-INJURYNEUROSTIMULATIONNEUROMODULATIONOXYGENATIONSIGNALEEG
ISSN
1471-2202
Abstract
Background: Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still unclear, and further investigation is needed. The present study proposes to use near-infrared spectroscopy (NIRS) to observe cerebral hemodynamic change caused by tFUS in a noninvasive manner. Results: The results show a transient increase of oxyhemoglobin and decrease of deoxyhemoglobin concentration in the mouse model induced by ultrasound stimulation of the somatosensory cortex with a frequency of 8 MHz but not in sham. In addition, the amplitude of hemodynamics change can be related to the peak intensity of the acoustic wave. Conclusion: High frequency 8 MHz ultrasound was shown to induce hemodynamic changes measured using NIRS through the intact mouse head. The implementation of NIRS offers the possibility of investigating brain response noninvasively for different tFUS parameters through cerebral hemodynamic change. © 2019 The Author(s).
URI
http://hdl.handle.net/20.500.11750/9741
DOI
10.1186/s12868-019-0493-9
Publisher
BioMed Central Ltd.
Related Researcher
  • Author Hwang, Jae Youn MBIS(Multimodal Biomedical Imaging and System) Laboratory
  • Research Interests Multimodal Imaging; High-Frequency Ultrasound Microbeam; Ultrasound Imaging and Analysis; 스마트 헬스케어; Biomedical optical system
Files:
Collection:
Department of Information and Communication EngineeringMBIS(Multimodal Biomedical Imaging and System) Laboratory1. Journal Articles


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