Cited 29 time in webofscience Cited 29 time in scopus

Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface

Title
Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface
Authors
Lee, SangHoonWang, HaoPeh, Wendy Yen XianHe, TianyiyiYen, Shih-ChengThakor, Nitish, VLee, Chengkuo
DGIST Authors
Lee, SangHoon
Issue Date
2019-06
Citation
Nano Energy, 60, 449-456
Type
Article
Article Type
Article
Author Keywords
Triboelectric nanogeneratorNeural clip interfacePelvic nerveUnderactive bladderMechano-neuromodulation
Keywords
NANOGENERATORPOLYMERSENSOR
ISSN
2211-2855
Abstract
Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface. The detailed stimulation parameters such as current, pulse width, and charges generated by the proposed TENG were investigated for the stimulation of autonomic pelvic nerve. In in vivo experiments, different beats per minute (BPM) were delivered to the nerves to investigate the effect of stimulation frequency on mechano-neurostimulation while monitoring changes in bladder pressure and the occurrence of micturition. Furthermore, different numbers of pulses were applied to stimulate the pelvic nerve. The bladder contractions with micturition were observed when applying more than 50 BPM as well as one pulse. Comparison of stimulation was performed using a commercial stimulator with the similar long-pulse widths as generated by TENGs. In addition, chronic implantation of flexible clip interface was demonstrated with functionality test of the interface. The results demonstrate that this technology may potentially be used for self-powered mechano-neuromodulation for bladder function in the future. © 2019
URI
http://hdl.handle.net/20.500.11750/9742
DOI
10.1016/j.nanoen.2019.03.082
Publisher
Elsevier BV
Related Researcher
  • Author Lee, SangHoon Neuro-Interfaced Robotics Lab
  • Research Interests Neural interface; Neuroprosthetics; Bioelectronics; Robotics
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringNeuro-Interfaced Robotics Lab1. Journal Articles


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