Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Minjee | ko |
dc.contributor.author | Kim, Myoung Ok | ko |
dc.contributor.author | Lee, Jinhee | ko |
dc.contributor.author | Jeong, Jain | ko |
dc.contributor.author | Sung, Yonghun | ko |
dc.contributor.author | Park, Song | ko |
dc.contributor.author | Kwon, Wookbong | ko |
dc.contributor.author | Jang, Soyoung | ko |
dc.contributor.author | Park, Si Jun | ko |
dc.contributor.author | Kim, Hyeng‐Soo | ko |
dc.contributor.author | Jang, Woo Young | ko |
dc.contributor.author | Kim, Sung Hyun | ko |
dc.contributor.author | Lee, Sanggyu | ko |
dc.contributor.author | Choi, Seong-Kyoon | ko |
dc.contributor.author | Ryoo, Zae Young | ko |
dc.date.accessioned | 2019-05-09T02:15:45Z | - |
dc.date.available | 2019-05-09T02:15:45Z | - |
dc.date.created | 2019-04-29 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | Scandinavian Journal of Immunology, v.89, no.6 | - |
dc.identifier.issn | 0300-9475 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/9821 | - |
dc.description.abstract | Serum amyloid A (SAA) is an acute phase protein with pro-inflammatory cytokine-like properties. Recent studies have revealed that SAA promoted interleukin-17 (IL-17) production by various cells, including γδ T cells. γδ T cells are innate immune cells and express Toll-like receptor 2 (TLR2) on their surface, which is one of the SAA receptors. In this study, we investigated the relationship between γδ T cells and SAA1 through TLR2, by using hepatic SAA1-overexpressing transgenic (TG) mice. By injecting CU-CPT22, which is a TLR2 inhibitor, into the mice, we confirmed that SAA1 induced IL-17 in γδ T cells through TLR2. In vitro studies have confirmed that SAA1 increased IL-17 secretion in γδ T cells in combination with IL-23. We also observed a thickened epidermis layer and granulocyte penetration into the skin similar to the pathology of psoriasis in TG mice. In addition, strongly expressed SAA1 and penetration of γδ T cells in the skin of TG mice were detected. The exacerbation of psoriasis is associated with an increase in IL-17 levels. Therefore, these symptoms were induced by IL-17-producing γδ T cells increased by SAA1. Our study confirmed that SAA1 was a prominent protein that increased IL-17 levels through TLR2 in γδ T cells, confirming the possibility that SAA1 may exacerbate inflammatory diseases through γδ T cells. © 2019 The Foundation for the Scandinavian Journal of Immunology | - |
dc.language | English | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Hepatic serum amyloid A1 upregulates interleukin-17 (IL-17) in γδ T cells through Toll-like receptor 2 and is associated with psoriatic symptoms in transgenic mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/sji.12764 | - |
dc.identifier.wosid | 000468316600003 | - |
dc.identifier.scopusid | 2-s2.0-85063992608 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Kim, Myoung Ok | - |
dc.contributor.nonIdAuthor | Lee, Jinhee | - |
dc.contributor.nonIdAuthor | Jeong, Jain | - |
dc.contributor.nonIdAuthor | Kwon, Wookbong | - |
dc.contributor.nonIdAuthor | Jang, Soyoung | - |
dc.contributor.nonIdAuthor | Park, Si Jun | - |
dc.contributor.nonIdAuthor | Kim, Hyeng‐Soo | - |
dc.contributor.nonIdAuthor | Jang, Woo Young | - |
dc.contributor.nonIdAuthor | Kim, Sung Hyun | - |
dc.contributor.nonIdAuthor | Lee, Sanggyu | - |
dc.contributor.nonIdAuthor | Ryoo, Zae Young | - |
dc.identifier.citationVolume | 89 | - |
dc.identifier.citationNumber | 6 | - |
dc.identifier.citationTitle | Scandinavian Journal of Immunology | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | acute phase reactants | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordAuthor | experimental animals | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | skin | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.contributor.affiliatedAuthor | Choi, Seong-Kyoon | - |
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