Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Choi, Young In | - |
dc.contributor.author | Choi, Eun-sook | - |
dc.contributor.author | Mun, Kwan Ho | - |
dc.contributor.author | Lee, Se Geun | - |
dc.contributor.author | Lee, Sung Jun | - |
dc.contributor.author | Jeong, Sang Won | - |
dc.contributor.author | Lee, Seung Woo | - |
dc.contributor.author | Kim, Hyun-Chul | - |
dc.date.accessioned | 2019-06-02T06:56:25Z | - |
dc.date.available | 2019-06-02T06:56:25Z | - |
dc.date.created | 2019-04-12 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/9875 | - |
dc.description.abstract | Polymeric micelles as drug delivery vehicles are popular owing to several advantages. In this study, a gemini amphiphile (gemini mPEG-Cys-PMT) consisting of hydrophilic poly(ethylene glycol) and hydrophobic poly(methionine) with cystine disulfide spacer was synthesized and its micellar properties for thiol- or reactive oxygen species (ROS)-dependent intracellular drug delivery were described. The cleavage of cystine linkage in a redox environment or the oxidation of methionine units in a ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated doxorubicin (DOX) to induce cytotoxicity against cancer cells. Further, the therapeutic effects of the DOX-loaded micelles were demonstrated using the KB cell line. This study shows that thiol and ROS dual-responsive gemini micelles are promising platforms for nano-drug delivery in various cancer therapies. © 2019 by the authors. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Dual-responsive Gemini Micelles for Efficient Delivery of Anticancer Therapeutics | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/polym11040604 | - |
dc.identifier.scopusid | 2-s2.0-85065907724 | - |
dc.identifier.bibliographicCitation | Polymers, v.11, no.4, pp.604 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | gemini micelles | - |
dc.subject.keywordAuthor | drug delivery systems | - |
dc.subject.keywordAuthor | disulfide–thiol exchange | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | COPOLYMER MICELLES | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PEG | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | SURFACTANTS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 604 | - |
dc.citation.title | Polymers | - |
dc.citation.volume | 11 | - |