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Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity

Title
Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity
Authors
Baek, MyunginMenon, VilasJessell, Thomas M.Hantman, Adam W.Dasen, Jeremy S.
DGIST Authors
Baek, Myungin
Issue Date
2019-05
Citation
Cell Reports, 27(9), 2620-2635
Type
Article
Article Type
Article
Keyword
DIFFERENTIAL EXPRESSION ANALYSIS; CLARKES COLUMN; REACHING MOVEMENTS; MOTOR-NEURONS; PROPRIOCEPTION; MUSCLE; RAT; SPECIFICITY; INPUTS; IMPAIRMENTS
ISSN
2211-1247
Abstract
Coordinated motor behaviors depend on feedback communication between peripheral sensory systems and central circuits in the brain and spinal cord. Relay of muscle- and tendon-derived sensory information to the CNS is facilitated by functionally and anatomically diverse groups of spinocerebellar tract neurons (SCTNs), but the molecular logic by which SCTN diversity and connectivity is achieved is poorly understood. We used single-cell RNA sequencing and genetic manipulations to define the mechanisms governing the molecular profile and organization of SCTN subtypes. We found that SCTNs relaying proprioceptive sensory information from limb and axial muscles are generated through segmentally restricted actions of specific Hox genes. Loss of Hox function disrupts SCTN-subtype-specific transcriptional programs, leading to defects in the connections between proprioceptive sensory neurons, SCTNs, and the cerebellum. These results indicate that Hox-dependent genetic programs play essential roles in the assembly of neural circuits necessary for communication between the brain and spinal cord. © 2019 The Author(s)Baek et al. show that Hox-transcription-factor-dependent programs govern the specification and connectivity of spinal interneurons that relay muscle-derived sensory information to the cerebellum. These findings shed light on the development of neural circuits required for proprioception—the perception of body position. © 2019 The Author(s)
URI
http://hdl.handle.net/20.500.11750/9913
DOI
10.1016/j.celrep.2019.04.113
Publisher
Elsevier B.V.
Related Researcher
Files:
Collection:
Department of Brain and Cognitive SciencesLocomotor NeuroCircuit Lab1. Journal Articles


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