The overarching aim of our lab is to understand the mechanisms of learning and memory at the levels of synaptic plasticity, dendritic biophysics, and neuronal ensembles. We develop molecular, optical, and computational tools for spatiotemporally mapping bioelectric activities to elucidate single-neuron computations and plasticity rules in behaving animals. These measurements will lay the groundwork to understand the molecular mechanisms of memory, with the ultimate goal of delaying or reversing memory dysfunctions. We further aim to extend these insights into the realm of brain-machine interface.