이영삼
Lee, Young-Sam학력
- 2004 ~ 2010University of Texas at Austin 박사
- 1997 ~ 1999서울대학교 석사
- 1993 ~ 1997서울대학교 학사
경력
- 2016 ~ Current대구경북과학기술원 / 조교수
- 2013 ~ 2016삼성종합기술원 / 수석연구원
- 2010 ~ 2013NIDDK, NIH / 박사후연구원
수상실적
- 2022 총장표창 / 대구경북과학기술원
- 2017 공로상 / DGIST
연구실 소개
- Senescence-Associated Mechanism Lab
-
Research SummaryOur objective is to restore cellular function in senescent stage by genome maintenance-based approachTo pursue the objective, we carry out the following research topics:1. Identify small molecules/genetic factors inducing physiological restoration of senescent cells and DNA repair capability. Figure out the mechanism of action in the restoration by the selected factors.2. Interpret the structure based function in DNA replication utilizing physiologically relevant damaged DNA substrates.3. Investigate the role of RNA transcripts (e.g. long noncoding RNAs) and their binding factors in DNA repair regarding cellular senescence.
Related Keyword
- "The ICL1 and MLS1 Genes, Integral to the Glyoxylate Cycle, are Essential and Specific for Caloric Restriction-Mediated Extension of Lifespan in Budding Yeast", Kwon, Young-Yon. (2024-09). The ICL1 and MLS1 Genes, Integral to the Glyoxylate Cycle, are Essential and Specific for Caloric Restriction-Mediated Extension of Lifespan in Budding Yeast. Advanced Biology, 8(9). doi: 10.1002/adbi.202400083
- "Brief guide to senescence assays using cultured mammalian cells", Kang, Eunseok. (2024-09). Brief guide to senescence assays using cultured mammalian cells. Molecules and Cells, 47(9). doi: 10.1016/j.mocell.2024.100102
- "Animal-free scaffold from brown algae provides a three-dimensional cell growth and differentiation environment for steak-like cultivated meat", Lee, Heejae. (2024-07). Animal-free scaffold from brown algae provides a three-dimensional cell growth and differentiation environment for steak-like cultivated meat. Food Hydrocolloids, 152. doi: 10.1016/j.foodhyd.2024.109944
- "From Homogeneity to Turing Pattern: Kinetically Controlled Self-Organization of Transmembrane Protein", Lee, Wonhee John. (2024-01). From Homogeneity to Turing Pattern: Kinetically Controlled Self-Organization of Transmembrane Protein. Nano Letters, 24(6), 1882–1890. doi: 10.1021/acs.nanolett.3c03637
- "What matters in aging is signaling for responsiveness", Park, Sang Chul. (2023-12). What matters in aging is signaling for responsiveness. Pharmacology and Therapeutics, 252. doi: 10.1016/j.pharmthera.2023.108560
- "The In vitro reconstituted the lens-specific intermediate filament with filensin and phakinin replicates the genotype-phenotype correlation for cataracts", Jeong, Jinju. (2024-03-25). The In vitro reconstituted the lens-specific intermediate filament with filensin and phakinin replicates the genotype-phenotype correlation for cataracts. 2024 Annual Meeting of the American Society for Biochemistry and Molecular Biology, S637–S637. doi: 10.1016/j.jbc.2024.106871
- "Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1", Lee, Young-Sam. (2022-08-25). Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1. 2022 한국분자세포생물학회 세포주기분과 Round table discussion 프로그램.
- "Controlling Aging Restoration of cellular senescence by recovery of mitochondrial function", 강현태. (2017-11-09). Controlling Aging Restoration of cellular senescence by recovery of mitochondrial function. 2017년 제 11회 대한미토콘드리아 연구의학회 학술대회 및 제 8회 한국분자세포생물학회 미토콘드리아 분과학회.
- "Controlling Aging Restoration of cellular senescence by modulating protein kinase activities", 강현태. (2017-11-03). Controlling Aging Restoration of cellular senescence by modulating protein kinase activities. 2017년 한국노화학회 추계학술대회.
- "How translesion polymerases conducts mutagenic DNA synthesis", Lee, Young-Sam. (2017-08-22). How translesion polymerases conducts mutagenic DNA synthesis. 2017년 한국단백질학회생물물리학회 연합학술대회.
연구 뉴스
- DGIST-아산병원 공동연구팀, 혈관 질환 치료를 위한 새로운 가능성 제시! 혈관 세포의 구멍 조절 현상을 밝혀내다 2024-02-08
- Joint Research Team between DGIST, Kyungpook National University, and KIOM Discovered Pathological Function of Alzheimer's Disease Risk Factor (APOE4) and Suggested New Treatment Options 2023-12-20
- The Research Team Led by DGIST Professor Dae-ha Seo has Successfully Developed New Technology for Optical Microscopy Analysis! Allows for the Drawing of Highly Precise Maps of Cell Membrane Lipid Rafts! 2023-12-20
- DGIST 서대하 교수팀, 광학현미경 분석 신기술 개발! 세포막 지질 뗏목의 초정밀 지도를 그리다! 2023-11-22
- DGIST-경북대-KIOM 공동연구팀, 알츠하이머 치매 원인 인자(APOE4)의 병리적 기능 발견으로 새로운 치료 방안 제시 2023-10-19
연구분야
미래유망 신기술(6T)
국가과학기술표준분류