Our objective is to restore cellular function in senescent stage by genome maintenance-based approach
To pursue the objective, we carry out the following research topics:
1. Identify small molecules/genetic factors inducing physiological restoration of senescent cells and DNA repair capability. Figure out the mechanism of action in the restoration by the selected factors.
2. Interpret the structure based function in DNA replication utilizing physiologically relevant damaged DNA substrates.
3. Investigate the role of RNA transcripts (e.g. long noncoding RNAs) and their binding factors in DNA repair regarding cellular senescence.
Advisor Professor : Lee, Young-Sam
Senescence-Associated Mechanism Lab Homepage