이병훈
Lee, Byung-Hoon학력
- 1999 ~ 2004University of Texas Southwestern Medical Center 박사
- 1996 ~ 1998서울대학교 석사
- 1990 ~ 1996서울대학교 학사
경력
- 2016 ~ CurrentDGIST / Assistant Professor
- 2018 ~ 2020Ubix Therapeutics / Scientific Advisory Board
- 2007 ~ 2016Havard Medical Center / 박사후연구원
- 2011 ~ 2011Proteostasis Therapeutics Inc / Scientific consultant
- 2006 ~ 2007MIT / 박사후연구원
수상실적
- 2020공로상
- 2018IUBMB YSP Fellowship
- 2016KSMCB International Conference Travel Grant Awards
- 2004Alfred Gilman Award
- 2001American Diabetes Association Internship Award
연구실 소개
- Lab of Protein Homeostasis and Drug Discovery
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Protein homeostasis through the ubiquitin-proteasome system (UPS) is critical in almost every aspect of basic and clinical biology. Our lab is particularly interested in understanding cellular protein quality control system and developing the strategies for improving proteostasis by manipulating the UPS. We will primarily investigate critical deubiquitination machinery in human pathophysiology. Our group will try to develop functional and chemical strategies to modulate the deubiquitination activities on the proteasome and at the upstream of proteasome to explore novel biological mechanisms in the ubiquitin-proteasome pathways. By developing new DUB inhibitors, we aim to define novel drug targets in protein quality control machinery and ultimately seek for potential therapeutic strategies for human health.
1. Discovery of novel deconjugation mechanisms in the ubiquitin-proteasome pathways for cell physiology2. Investigation of novel regulatory mechanisms in ubiquitin deconjugation activities for proteasome function3. Defining deubiquitinating enzymes as novel drug targets in oncogenesis and other human diseases by functional and chemical studies4. Defining proteasome and deubiquitinating enzymes as novel drug targets in human longevity by combinatorial approaches of chemical and functional studies
Related Keyword
- "Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner", Autophagy, v.20, no.12, pp.2752 - 2768
- "Biallelic USP14 variants cause a syndromic neurodevelopmental disorder", Genetics in Medicine, v.26, no.6
- "Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation", Cells, v.13, no.11
- "Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models", Blood Advances, v.7, no.1, pp.92 - 105
- "Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1", Nature Communications, v.13, no.1
연구 뉴스
- 단백질분해 운명 결정의 근본적인 해답 발견, 분해기반 신약개발을 위한 새로운 패러다임 제공 2025-01-21
- Study shows first signs of cross-talk between RNA surveillance and silencing systems 2025-01-21
- DGIST-IBS, 생명현상의 근원인 유전자 발현 원리 규명해 2025-01-21
- DGIST 연구팀, 2019년도 기초연구실 신규과제 선정 2025-01-21
- 뉴바이올로지전공 - ‘정크 단백질’을 분해하라 2025-01-21
연구분야
미래유망 신기술(6T)
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20.
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201.
20114. 생명현상 및 기능연구
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국가과학기술표준분류
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LA. 생명과학
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LA06. 생화학/구조생물학
LA0601. 단백질 구조와 기능
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LA. 생명과학
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LA01. 분자세포생물학
LA0101. 신호전달
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LA. 생명과학
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LA01. 분자세포생물학
LA0103. 세포분화/사멸
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LC. 보건의료
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LC01. 의생명과학
LC0103. 생화학
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12대 국가전략기술 분야
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첨단바이오
유전자·세포 치료