Researchers & Labs

researcher image '이병훈'

이병훈

Lee, Byung-Hoon

Department of New Biology

 학력

  • 1999 ~ 2004University of Texas Southwestern Medical Center 박사
  • 1996 ~ 1998서울대학교 석사
  • 1990 ~ 1996서울대학교 학사

 경력

  • 2016 ~ CurrentDGIST / Assistant Professor
  • 2018 ~ 2020Ubix Therapeutics / Scientific Advisory Board
  • 2007 ~ 2016Havard Medical Center / 박사후연구원
  • 2011 ~ 2011Proteostasis Therapeutics Inc / Scientific consultant
  • 2006 ~ 2007MIT / 박사후연구원

 수상실적

  • 2020공로상
  • 2018IUBMB YSP Fellowship
  • 2016KSMCB International Conference Travel Grant Awards
  • 2004Alfred Gilman Award
  • 2001American Diabetes Association Internship Award

연구실 소개

Lab of Protein Homeostasis and Drug Discovery

Lab of Protein Homeostasis and Drug Discovery cover image

Protein homeostasis through the ubiquitin-proteasome system (UPS) is critical in almost every aspect of basic and clinical biology. Our lab is particularly interested in understanding cellular protein quality control system and developing the strategies for improving proteostasis by manipulating the UPS. We will primarily investigate critical deubiquitination machinery in human pathophysiology. Our group will try to develop functional and chemical strategies to modulate the deubiquitination activities on the proteasome and at the upstream of proteasome to explore novel biological mechanisms in the ubiquitin-proteasome pathways. By developing new DUB inhibitors, we aim to define novel drug targets in protein quality control machinery and ultimately seek for potential therapeutic strategies for human health.
1. Discovery of novel deconjugation mechanisms in the ubiquitin-proteasome pathways for cell physiology2. Investigation of novel regulatory mechanisms in ubiquitin deconjugation activities for proteasome function3. Defining deubiquitinating enzymes as novel drug targets in oncogenesis and other human diseases by functional and chemical studies4. Defining proteasome and deubiquitinating enzymes as novel drug targets in human longevity by combinatorial approaches of chemical and functional studies

연구분야

미래유망 신기술(6T)

  • 20.

    • 201.

      • 20114. 생명현상 및 기능연구

국가과학기술표준분류

  • LA. 생명과학

    • LA06. 생화학/구조생물학

      • LA0601. 단백질 구조와 기능

  • LA. 생명과학

    • LA01. 분자세포생물학

      • LA0101. 신호전달

  • LA. 생명과학

    • LA01. 분자세포생물학

      • LA0103. 세포분화/사멸

  • LC. 보건의료

    • LC01. 의생명과학

      • LC0103. 생화학

12대 국가전략기술 분야

  • 첨단바이오

    • 유전자·세포 치료