Protein homeostasis through the ubiquitin-proteasome system (UPS) is critical in almost every aspect of basic and clinical biology. Our lab is particularly interested in understanding cellular protein quality control system and developing the strategies for improving proteostasis by manipulating the UPS. We will primarily investigate critical deubiquitination machinery in human pathophysiology. Our group will try to develop functional and chemical strategies to modulate the deubiquitination activities on the proteasome and at the upstream of proteasome to explore novel biological mechanisms in the ubiquitin-proteasome pathways. By developing new DUB inhibitors, we aim to define novel drug targets in protein quality control machinery and ultimately seek for potential therapeutic strategies for human health.
1. Discovery of novel deconjugation mechanisms in the ubiquitin-proteasome pathways for cell physiology
2. Investigation of novel regulatory mechanisms in ubiquitin deconjugation activities for proteasome function
3. Defining deubiquitinating enzymes as novel drug targets in oncogenesis and other human diseases by functional and chemical studies
4. Defining proteasome and deubiquitinating enzymes as novel drug targets in human longevity by combinatorial approaches of chemical and functional studies
Advisor Professor : Lee, Byung Hoon