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Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression

Title
Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression
Authors
Kim, Hyun JungLee, SukmookOh, Yong-SeokChang, Ha KyunKim, Young SangHong, Sung HeeKim, Jung YongPark, Young-WhanLee, Song-JaeSong, Seong-WonKim, Jung JuHeo, Kyun
DGIST Authors
Oh, Yong-Seok
Issue Date
2019-07
Citation
Frontiers in Oncology, 9
Type
Article
Article Type
Article
Author Keywords
HGFhumanized monoclonal antibodyovarian cancermetastasisYYB-101
Keywords
PEGYLATED LIPOSOMAL DOXORUBICINSMALL-MOLECULE INHIBITORC-METPHASE-IIEUROPEAN-ORGANIZATIONGYNECOLOGIC-ONCOLOGYSURFACE EPITHELIUMBRCA2 MUTATIONSSTAGE OVARIANFACTOR HGF
ISSN
2234-943X
Abstract
Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an in vivo ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.
URI
http://hdl.handle.net/20.500.11750/10295
DOI
10.3389/fonc.2019.00571
Publisher
Frontiers Media S.A.
Related Researcher
  • Author Oh, Yong-Seok Molecular Psychiatry Lab
  • Research Interests Monoaminergic regulation of the CNS and mood;anxiety disorder; 모노아민 (세로토닌, 도파민)에 의한 신경조절과 기분;불안 장애 기전 연구
Files:
Collection:
Department of Brain and Cognitive SciencesMolecular Psychiatry Lab1. Journal Articles


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