Cited 0 time in webofscience Cited 0 time in scopus

Atmospheric pressure mass spectrometric imaging of bio-tissue specimen using electrospray-assisted CW laser desorption and ionization source

Title
Atmospheric pressure mass spectrometric imaging of bio-tissue specimen using electrospray-assisted CW laser desorption and ionization source
Authors
Kim, Jae YoungLee, SunYoungMoon, DaeWonPark, Ji-WonLim, Dong-KwonSong, Cheol
DGIST Authors
Kim, Jae Young; Song, Cheol
Issue Date
2019-07
Citation
Biointerphases, 14(4), 041001
Type
Article
Article Type
Article
Keywords
METABOLITESPROTEINS
ISSN
1934-8630
Abstract
When a tissue slice pretreated with gold nanoparticles is irradiated with a focused 532-nm continuous wave laser, desorption is observed to be uniform and stable, and its shape is sharp and steep. However, since the desorbed molecules are still electrically neutral particles in atmospheric pressure (AP), additional procedure of ionizing them is necessary for AP mass spectrometry (AP-MS) analysis. Therefore, the authors have combined an electrospray device with a simple chamber connected to the airflow-assisted particle transport equipment mounted at the mass spectrometer inlet. Subsequent ionization processes using an electrospray device enable the detection of several types of diacylglycerol molecules above 500 Da, which cannot be detected with the use of AP plasma jets. The authors also developed a remote AP-MS using a long and flexible sampling probe and a fiber laser with a slight modification of the proposed AP desorption and ionization method. © 2019 Author(s).
URI
http://hdl.handle.net/20.500.11750/10377
DOI
10.1116/1.5099563
Publisher
American Vacuum Society
Related Researcher
  • Author Song, Cheol Intelligent Bio-OptoMechatronics Lab
  • Research Interests Handheld medical robotics; Smart robotic microsurgery; Smart neuro-rehabilitation; Bio-photonic sensing and imaging
Files:
Collection:
Department of Robotics EngineeringRobotics Engineering Research Center1. Journal Articles
Department of Robotics EngineeringIntelligent Bio-OptoMechatronics Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE