Cited 0 time in webofscience Cited 0 time in scopus

Increased accumulation of Staufen in nucleus contributes to C9ALS/FTD pathology

Title
Increased accumulation of Staufen in nucleus contributes to C9ALS/FTD pathology
Translated Title
핵 속에 축적된 Staufen 단백질이 C9ALS/FTD 병리 기전에 기여
Authors
Eun Seon Kim
DGIST Authors
Eun Seon Kim
Advisor(s)
이성배
Co-Advisor(s)
Ho Min Kim
Issue Date
2019
Available Date
2019-08-23
Degree Date
2019-08-01
Type
Thesis
Description
ALS/FTD, C9ORF72, DPR, Staufen, Drosophila, 루게릭 병, 전두측두엽 치매, 초파리
Table Of Contents
Abstract i List of contents ii List of figures iii I. INTRODUCTION 1 1.1 C9ORF72 expansion causes ALS/FTD pathology 1 1.2 Arginine-rich DPR proteins mainly contribute to C9ALS/FTD pathology 2 1.3 Pathogenic role of Staufen remains elusive in C9ALS/FTD pathology 3 II. MATERIALS AND METHODS 5 III. RESULTS 15 3.1 Arginine-rich DPR proteins increase nuclear accumulation of Staufen 15 3.2 Increased accumulation of nuclear Staufen partially co-localizes with heterochromatin 28 3.3 Increased nuclear accumulation of Staufen is mRNA dependent 34 3.4 Loss of Staufen rescues poly(PR)-mediated toxicity 43 IV. DISCUSSION 47 V. REFERENCES 49 VI. SUMMARY (국문요약) 53
URI
http://dgist.dcollection.net/common/orgView/200000218831
http://hdl.handle.net/20.500.11750/10448
DOI
10.22677/thesis.200000218831
Degree
Master
Department
Brain and Cognitive Sciences
University
DGIST
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesETCETC


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE