Title

Increased accumulation of Staufen in nucleus contributes to C9ALS/FTD pathology

Alternative Title

핵 속에 축적된 Staufen 단백질이 C9ALS/FTD 병리 기전에 기여

DGIST Authors

Kim, Eun Seon ; Kim, Ho Min ; Lee, Sung Bae

Advisor

이성배

Co-Advisor(s)

Ho Min Kim

Issued Date

2019

Awarded Date

2019-08

Citation

Eun Seon Kim. (2019). Increased accumulation of Staufen in nucleus contributes to C9ALS/FTD pathology. doi: 10.22677/thesis.200000218831

Type

Thesis

Description

ALS/FTD, C9ORF72, DPR, Staufen, Drosophila, 루게릭 병, 전두측두엽 치매, 초파리

Table Of Contents

Abstract i
List of contents ii
List of figures iii

I. INTRODUCTION 1
1.1 C9ORF72 expansion causes ALS/FTD pathology 1
1.2 Arginine-rich DPR proteins mainly contribute to C9ALS/FTD pathology 2
1.3 Pathogenic role of Staufen remains elusive in C9ALS/FTD pathology 3

II. MATERIALS AND METHODS 5

III. RESULTS 15
3.1 Arginine-rich DPR proteins increase nuclear accumulation of Staufen 15
3.2 Increased accumulation of nuclear Staufen partially co-localizes with heterochromatin 28
3.3 Increased nuclear accumulation of Staufen is mRNA dependent 34
3.4 Loss of Staufen rescues poly(PR)-mediated toxicity 43

IV. DISCUSSION 47

V. REFERENCES 49

VI. SUMMARY (국문요약) 53

URI

http://dgist.dcollection.net/common/orgView/200000218831
http://hdl.handle.net/20.500.11750/10448

DOI

10.22677/thesis.200000218831

Degree

Master

Department

Department of Brain and Cognitive Sciences

Publisher

DGIST

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