Increased accumulation of Staufen in nucleus contributes to C9ALS/FTD pathology
- Title
- Increased accumulation of Staufen in nucleus contributes to C9ALS/FTD pathology
- Alternative Title
- 핵 속에 축적된 Staufen 단백질이 C9ALS/FTD 병리 기전에 기여
- Author(s)
- Eun Seon Kim
- DGIST Authors
- Kim, Eun Seon ; Kim, Ho Min ; Lee, Sung Bae
- Advisor
- 이성배
- Co-Advisor(s)
- Ho Min Kim
- Issued Date
- 2019
- Awarded Date
- 2019-08
- Type
- Thesis
- Description
- ALS/FTD, C9ORF72, DPR, Staufen, Drosophila, 루게릭 병, 전두측두엽 치매, 초파리
- Table Of Contents
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Abstract i
List of contents ii
List of figures iii
I. INTRODUCTION 1
1.1 C9ORF72 expansion causes ALS/FTD pathology 1
1.2 Arginine-rich DPR proteins mainly contribute to C9ALS/FTD pathology 2
1.3 Pathogenic role of Staufen remains elusive in C9ALS/FTD pathology 3
II. MATERIALS AND METHODS 5
III. RESULTS 15
3.1 Arginine-rich DPR proteins increase nuclear accumulation of Staufen 15
3.2 Increased accumulation of nuclear Staufen partially co-localizes with heterochromatin 28
3.3 Increased nuclear accumulation of Staufen is mRNA dependent 34
3.4 Loss of Staufen rescues poly(PR)-mediated toxicity 43
IV. DISCUSSION 47
V. REFERENCES 49
VI. SUMMARY (국문요약) 53
- URI
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http://dgist.dcollection.net/common/orgView/200000218831
http://hdl.handle.net/20.500.11750/10448
- Degree
- Master
- Department
- Department of Brain and Cognitive Sciences
- Publisher
- DGIST
- Related Researcher
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Lee, Sung Bae
- Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
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- Appears in Collections:
- Department of Brain Sciences Theses Master
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