TDP-43 regulates local membrane trafficking through Golgi outposts in Drosophila neurons
- Title
- TDP-43 regulates local membrane trafficking through Golgi outposts in Drosophila neurons
- Author(s)
- Sung Soon Park
- DGIST Authors
- Lee, Sung Bae ; Park, Sung Soon ; Kim, Ho Min
- Advisor
- 이성배
- Co-Advisor(s)
- Ho Min Kim
- Issued Date
- 2019
- Awarded Date
- 2019-08
- Type
- Thesis
- Description
- TDP-43, Golgi outposts, Splicing, Rab GTPases, endo-lysosomal pathway
- Table Of Contents
-
Abstract ····················································································i
List of contents ········································································ii
List of tables ··········································································iii
List of figures ·········································································iv
I. Introduction········································································1
II. Materials and Methods ·························································3
III. Results···········································································10
3.1 dTDP-43 overexpression increases the number of Golgi outposts ······················10
3.2 Nuclear dTDP-43 regulates the number of dendritic GOPs through pre-mRNA
splicing function ················································································28
3.3 Increased level of Rab GTPase effectors by dTDP-43 overexpression contributes
to GOP synthesis ···············································································43
3.4 dTDP-43-induced GOPs regulate membrane trafficking to late endo-lysosomes
and plasma membrane in dendrites···························································58
IV. Discussion·······································································66
V. References ·······································································72
VI. Summary in Korean··························································76
- URI
-
http://dgist.dcollection.net/common/orgView/200000219092
http://hdl.handle.net/20.500.11750/10450
- Degree
- Master
- Department
- Department of Brain and Cognitive Sciences
- Publisher
- DGIST
- Related Researcher
-
-
Lee, Sung Bae
- Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
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- Appears in Collections:
- Department of Brain Sciences Theses Master
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