Abstract ····················································································i List of contents ········································································ii List of tables ··········································································iii List of figures ·········································································iv I. Introduction········································································1 II. Materials and Methods ·························································3 III. Results···········································································10 3.1 dTDP-43 overexpression increases the number of Golgi outposts ······················10 3.2 Nuclear dTDP-43 regulates the number of dendritic GOPs through pre-mRNA splicing function ················································································28 3.3 Increased level of Rab GTPase effectors by dTDP-43 overexpression contributes
to GOP synthesis ···············································································43 3.4 dTDP-43-induced GOPs regulate membrane trafficking to late endo-lysosomes and plasma membrane in dendrites···························································58 IV. Discussion·······································································66 V. References ·······································································72 VI. Summary in Korean··························································76
