Cited 0 time in webofscience Cited 0 time in scopus

TDP-43 regulates local membrane trafficking through Golgi outposts in Drosophila neurons

Title
TDP-43 regulates local membrane trafficking through Golgi outposts in Drosophila neurons
Authors
Sung Soon Park
DGIST Authors
Park, Sung Soon; Kim, Ho Min; Lee, Sung Bae
Advisor(s)
이성배
Co-Advisor(s)
Ho Min Kim
Issue Date
2019
Available Date
2019-08-23
Degree Date
2019-08
Type
Thesis
Description
TDP-43, Golgi outposts, Splicing, Rab GTPases, endo-lysosomal pathway
Table Of Contents
Abstract ····················································································i List of contents ········································································ii List of tables ··········································································iii List of figures ·········································································iv I. Introduction········································································1 II. Materials and Methods ·························································3 III. Results···········································································10 3.1 dTDP-43 overexpression increases the number of Golgi outposts ······················10 3.2 Nuclear dTDP-43 regulates the number of dendritic GOPs through pre-mRNA splicing function ················································································28 3.3 Increased level of Rab GTPase effectors by dTDP-43 overexpression contributes to GOP synthesis ···············································································43 3.4 dTDP-43-induced GOPs regulate membrane trafficking to late endo-lysosomes and plasma membrane in dendrites···························································58 IV. Discussion·······································································66 V. References ·······································································72 VI. Summary in Korean··························································76
URI
http://dgist.dcollection.net/common/orgView/200000219092
http://hdl.handle.net/20.500.11750/10450
DOI
10.22677/thesis.200000219092
Degree
Master
Department
Department of Brain and Cognitive Sciences
University
DGIST
Related Researcher
  • Author Lee, Sung Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesThesesMaster


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE