Title

TDP-43 regulates local membrane trafficking through Golgi outposts in Drosophila neurons

DGIST Authors

Lee, Sung Bae ; Park, Sung Soon ; Kim, Ho Min

Advisor

이성배

Co-Advisor(s)

Ho Min Kim

Issued Date

2019

Awarded Date

2019-08

Citation

Sung Soon Park. (2019). TDP-43 regulates local membrane trafficking through Golgi outposts in Drosophila neurons. doi: 10.22677/thesis.200000219092

Type

Thesis

Description

TDP-43, Golgi outposts, Splicing, Rab GTPases, endo-lysosomal pathway

Table Of Contents

Abstract ····················································································i
List of contents ········································································ii
List of tables ··········································································iii
List of figures ·········································································iv
I. Introduction········································································1
II. Materials and Methods ·························································3
III. Results···········································································10
3.1 dTDP-43 overexpression increases the number of Golgi outposts ······················10
3.2 Nuclear dTDP-43 regulates the number of dendritic GOPs through pre-mRNA
splicing function ················································································28
3.3 Increased level of Rab GTPase effectors by dTDP-43 overexpression contributes

to GOP synthesis ···············································································43
3.4 dTDP-43-induced GOPs regulate membrane trafficking to late endo-lysosomes
and plasma membrane in dendrites···························································58
IV. Discussion·······································································66
V. References ·······································································72
VI. Summary in Korean··························································76

URI

http://dgist.dcollection.net/common/orgView/200000219092
http://hdl.handle.net/20.500.11750/10450

DOI

10.22677/thesis.200000219092

Degree

Master

Department

Department of Brain and Cognitive Sciences

Publisher

DGIST

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