Cited 28 time in webofscience Cited 27 time in scopus

Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation

Title
Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation
Authors
Qazi, RazaGomez, Adrian M.Castro, Daniel C.Zou, ZhananSim, Joo YongXiong, YanyuAbdo, JonasKim, Choong YeonAnderson, AveryLohner, FrederikByun, Sang-HyukLee, Byung ChulJang, Kyung-InXiao, JianliangBruchas, Michael R.Jeong, Jae-Woong
DGIST Authors
Jang, Kyung-In
Issue Date
2019-08
Citation
Nature Biomedical Engineering, 3(8), 655-669
Type
Article
Article Type
Article
Keywords
NEURAL PROBESPHARMACOLOGYCIRCUITSOPTOELECTRONICSOPTOGENETICSIMPLANTSDELIVERYSYSTEM
ISSN
2157-846X
Abstract
Both in vivo neuropharmacology and optogenetic stimulation can be used to decode neural circuitry, and can provide therapeutic strategies for brain disorders. However, current neuronal interfaces hinder long-term studies in awake and freely behaving animals, as they are limited in their ability to provide simultaneous and prolonged delivery of multiple drugs, are often bulky and lack multifunctionality, and employ custom control systems with insufficiently versatile selectivity for output mode, animal selection and target brain circuits. Here, we describe smartphone-controlled, minimally invasive, soft optofluidic probes with replaceable plug-like drug cartridges for chronic in vivo pharmacology and optogenetics with selective manipulation of brain circuits. We demonstrate the use of the probes for the control of the locomotor activity of mice for over four weeks via programmable wireless drug delivery and photostimulation. Owing to their ability to deliver both drugs and photopharmacology into the brain repeatedly over long time periods, the probes may contribute to uncovering the basis of neuropsychiatric diseases. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
URI
http://hdl.handle.net/20.500.11750/10488
DOI
10.1038/s41551-019-0432-1
Publisher
Nature Publishing Group
Related Researcher
  • Author Jang, Kyung-In Bio-integrated Electronics Lab
  • Research Interests Extreme mechanics; Stand-alone electronics; Heterogeneous materials; Biocompatible interfaces
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringBio-integrated Electronics Lab1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE