Cited 3 time in webofscience Cited 2 time in scopus

Hepatic Cellular Distribution of Silica Nanoparticles by Surface Energy Modification

Title
Hepatic Cellular Distribution of Silica Nanoparticles by Surface Energy Modification
Authors
Lee, A-RangNam, KibeomLee, Byeong JunLee, Seoung-WooBaek, Su-MinBang, Jun-SunChoi, Seong-KyoonPark, Sang-JoonKim, Tae-HwanJeong, Kyu-ShikLee, Dong YunPark, Jin-Kyu
DGIST Authors
Choi, Seong-Kyoon
Issue Date
2019-08
Citation
International Journal of Molecular Sciences, 20(15)
Type
Article
Article Type
Article
Author Keywords
silica nanoparticlessurface energy modificationNP-based drug delivery
Keywords
SINUSOIDAL ENDOTHELIAL-CELLSPLASMA-PROTEINSSTELLATE CELLSHEPATOCELLULAR-CARCINOMATARGETED DELIVERYINTERFERING RNASSIZEHEPATOCYTESRECEPTORDISEASE
ISSN
1661-6596
Abstract
The cellular distribution of silica nanoparticles (NPs) in the liver is not well understood. Targeting specific cells is one of the most important issues in NP-based drug delivery to improve delivery efficacy. In this context, the present study analyzed the relative cellular distribution pattern of silica NPs in the liver, and the effect of surface energy modification on NPs. Hydrophobic NP surface modification enhanced NP delivery to the liver and liver sinusoid fFendothelial cells (LSECs). Conversely, hydrophilic NP surface modification was commensurate with targeting hepatic stellate cells (HSCs) rather than other cell types. There was no notable difference in NP delivery to Kupffer cells or hepatocytes, regardless of hydrophilic or hydrophobic NP surface modification, suggesting that both the targeting of hepatocytes and evasion of phagocytosis by Kupffer cells are not associated with surface energy modification of silica NPs. This study provides useful information to target specific cell types using silica NPs, as well as to understand the relationship between NP surface energy and the NP distribution pattern in the liver, thereby helping to establish strategies for cell targeting using various NPs. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/10615
DOI
10.3390/ijms20153812
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Related Researcher
Files:
Collection:
Division of Biotechnology1. Journal Articles


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