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Presenilin-2 N141I Knockin Mice as a Model of Alzheimer’s Disease

Title
Presenilin-2 N141I Knockin Mice as a Model of Alzheimer’s Disease
Author(s)
Ji-Eun Gim
DGIST Authors
Yu, Seong-WoonGim, Ji-EunLee, Byung-Hoon
Advisor
유성운
Co-Advisor(s)
Byung-Hoon Lee
Issued Date
2019
Awarded Date
2019-02
Type
Thesis
Table Of Contents
1. Introduction
2. Material and Methods
2.1 Cell culture 7
2.2 Western blotting analysis (WB) 7
2.3 RNA extraction and Quantitative real-time polymerase chain reaction (qRT-PCR) 8
2.4 Reagents and antibodies 11
2.5 CORT measurement 11
2.6 Y-maze test 11
2.7 Statistical analysis 12

3. Results
3.1 Generation of PS2 N141I KI mice 13
3.2 Cognitive decline was detected in PS2 N141I KI mice 15
3.3 PS2 CTF levels are decreased in PS2 N141I KI mice 19
3.4 CORT treatment increased PS2 level in HCN cells 21
3.4 PS2 expression in CORT treated HCN cells is regulated by autophagy 23

4. Discussion
Reference
Abstract in Korean
URI
http://dgist.dcollection.net/common/orgView/200000171529

http://hdl.handle.net/20.500.11750/10698
DOI
10.22677/thesis.200000171529
Degree
MASTER
Department
Brain and Cognitive Sciences
Publisher
DGIST
Related Researcher
  • 유성운 Yu, Seong-Woon 뇌과학과
  • Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
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Department of Brain Sciences Theses Master

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