Cited 24 time in webofscience Cited 22 time in scopus

Multifunctional Nanorobot System for Active Therapeutic Delivery and Synergistic Chemo-photothermal Therapy

Title
Multifunctional Nanorobot System for Active Therapeutic Delivery and Synergistic Chemo-photothermal Therapy
Authors
Jin, ZhenNguyen, Kim.TienGo, GwangjunKang, ByungjeonMin, Hyun-KiKim, Seok-JaeKim, YunLi, HaoKim, Chang-SeiLee, SeonminPark, SukhoKim, Kyu-PyoHuh, Kang MooSong, JihwanPark, Jong-OhChoi, Eunpyo
DGIST Authors
Park, Sukho
Issue Date
2019-12
Citation
Nano Letters, 19(12), 8550-8564
Type
Article
Article Type
Article
Author Keywords
Nanorobot systemactive tumor targetingcontrolled drug releasechemo-photothermal therapycancer treatment
Keywords
IRON-OXIDE NANOPARTICLESDRUG-DELIVERYCANCERNANOMOTORSBACTERIATRANSPORTATIONNANOLIPOSOMESHYPERTHERMIACHEMOTHERAPYGUIDANCE
ISSN
1530-6984
Abstract
Nanorobots are safe and exhibit powerful functionalities, including delivery, therapy, and diagnosis. Therefore, they are in high demand for the development of new cancer therapies. Although many studies have contributed to the progressive development of the nanorobot system for anticancer drug delivery, these systems still face some critical limitations, such as potentially toxic materials in the nanorobots, unreasonable sizes for passive targeting, and the lack of several essential functions of the nanorobot for anticancer drug delivery including sensing, active targeting, controlling drug release, and sufficient drug loading capacity. Here, we developed a multifunctional nanorobot system capable of precise magnetic control, sufficient drug loading for chemotherapy, light-triggered controlled drug release, light absorption for photothermal therapy, enhanced magnetic resonance imaging, and tumor sensing. The developed nanorobot system exhibits an in vitro synergetic antitumor effect of photothermal therapy and chemotherapy and outstanding tumor-targeting efficiency in both in vitro and in vivo environments. The results of this study encourage further explorations of an efficient active drug delivery system for cancer treatment and the development of nanorobot systems for other biomedical applications. © 2019 American Chemical Society.
URI
http://hdl.handle.net/20.500.11750/10930
DOI
10.1021/acs.nanolett.9b03051
Publisher
American Chemical Society
Related Researcher
  • Author Park, Sukho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles


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