Cited 12 time in webofscience Cited 12 time in scopus

Graphene quantum dots-decorated hollow copper sulfide nanoparticles for controlled intracellular drug release and enhanced photothermal-chemotherapy

Title
Graphene quantum dots-decorated hollow copper sulfide nanoparticles for controlled intracellular drug release and enhanced photothermal-chemotherapy
Authors
Zheng, ShaohuiJin, ZhenHan, CuipingLi, JingjingXu, HangPark, SukhoPark, Jong-OhChoi, EunpyoXu, Kai
DGIST Authors
Park, Sukho
Issue Date
2020-01
Citation
Journal of Materials Science, 55(3), 1184-1197
Type
Article
Article Type
Article
Keywords
MULTIFUNCTIONAL NANOPARTICLESPHOTODYNAMIC THERAPYDELIVERY SYSTEMMICELLESPLATFORMDESIGN
ISSN
0022-2461
Abstract
Graphene quantum dots (GQDs)-decorated hollow copper sulfide nanoparticles (CuS NPs) were developed as a multifunctional platform for controlled intracellular drug release and enhanced photothermal-chemotherapy. The CuS NPs were firstly synthesized to encapsulate anticancer drug doxorubicin (DOX) followed by the GQDs decoration on the surface of CuS NPs. The prepared NPs exhibited good crystal structure, uniform nanosize, excellent colloidal stability, high drug encapsulation and enhanced optical absorbance. Moreover, the drug release was successfully triggered from the DOX-CuS@GQDs NPs under high temperature and (near-infrared) NIR laser irradiation. Encouraged by this result, we moved to investigate the intracellular drug release behavior under NIR laser irradiation on MDA-MB-231 cells. The confocal images and flow cytometry analysis indicated a significant NIR-triggered DOX release within MDA-MB-231 cells after cellular uptake. Furthermore, the CuS NPs could readily convert light energy to heat to photothermally ablate the cancer cells under NIR laser irradiation, and the photothermal ablation effect was further enhanced by the capping of GQDs on CuS NPs. The combined photothermal therapy and chemotherapy of the prepared DOX-CuS@GQDs NPs also enabled a synergistic therapeutic effect on cancer cells. Therefore, the prepared DOX-CuS@GQDs NPs provided a novel promising platform for cancer therapy with controlled intracellular drug release and combined photothermal-chemotherapy. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
URI
http://hdl.handle.net/20.500.11750/10957
DOI
10.1007/s10853-019-04062-x
Publisher
Springer
Related Researcher
  • Author Park, Sukho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
Files:
There are no files associated with this item.
Collection:
Department of Robotics EngineeringMultiscale Biomedical Robotics Laboratory1. Journal Articles


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