Cited 16 time in webofscience Cited 13 time in scopus

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease

Title
ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease
Authors
Jeong, WoojinLee, HyeinCho, SukheeSeo, Jinsoo
DGIST Authors
Seo, Jinsoo
Issue Date
2019-12
Citation
Molecules and Cells, 42(11), 739-746
Type
Article
Article Type
Review
Author Keywords
A betaAlzheimer&aposs diseaseApoE4apolipoproteincholesterol
Keywords
MICROGLIA-LIKE CELLSAPOLIPOPROTEIN-EMOUSE MODELIN-VITROA-BETANEURONSRISKHYPERCHOLESTEROLEMIANEURODEGENERATIONMETABOLISM
ISSN
1016-8478
Abstract
Significant knowledge about the pathophysiology of Alzheimer's disease (AD) has been gained in the last century; however, the understanding of its causes of onset remains limited. Late-onset AD is observed in about 95% of patients, and APOE4-encoding apolipoprotein E4 (ApoE4) is strongly associated with these cases. As an apolipoprotein, the function of ApoE in brain cholesterol transport has been extensively studied and widely appreciated. Development of new technologies such as human-induced pluripotent stem cells (hiPSCs) and CRISPR-Cas9 genome editing tools have enabled us to develop human brain model systems in vitro and readily manipulate genomic information. In the context of these advances, recent studies provide strong evidence that abnormal cholesterol metabolism by ApoE4 could be linked to AD-associated pathology. In this review, we discuss novel discoveries in brain cholesterol dysregulation by ApoE4. We further elaborate cell type-specific roles in cholesterol regulation of four major brain cell types, neurons, astrocytes, microglia, and oligodendrocytes, and how its dysregulation can be linked to AD pathology.
URI
http://hdl.handle.net/20.500.11750/11022
DOI
10.14348/molcells.2019.0200
Publisher
한국분자세포생물학회
Related Researcher
  • Author Seo, Jinsoo Laboratory of Aging Brain
  • Research Interests iPSC; Alzheimer's disease; Neurodegeneration; Synapse; Neuroscience
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesLaboratory of Aging Brain1. Journal Articles


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