Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jae Yeon | - |
dc.contributor.author | Cho, Bongki | - |
dc.contributor.author | Moon, Cheil | - |
dc.date.accessioned | 2020-02-27T09:00:16Z | - |
dc.date.available | 2020-02-27T09:00:16Z | - |
dc.date.created | 2020-01-15 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/11395 | - |
dc.description.abstract | Kim et al. reveal that Abl1 is required in early-born olfactory bulb (OB) interneurons during postnatal neurodevelopment. The Abl1-Dcx axis regulates OB circuit formation to support innate olfactory behaviors. The authors propose that Abl1-Dcx is the crucial temporal-specific signal underlying anatomical and/or functional development of postnatal early-born OB interneurons. © 2019 The Author(s)More than one-half of the interneurons in a mouse olfactory bulb (OB) develop during the first week after birth and predominantly connect to excitatory tufted cells near the superficial granule cell layer (sGCL), unlike late-born interneurons. However, the molecular mechanisms underlying the temporal specification are yet to be identified. In this study, we determined the role of Abelson tyrosine-protein kinase 1 (Abl1) in the temporal development of early-born OB interneurons. Lentiviral knockdown of Abl1 disrupts the sGCL circuit of early-born interneurons through defects in function and circuit integration, resulting in olfactory hyper-sensitivity. We show that doublecortin (Dcx) is phosphorylated by Abl1, which contributes to the stabilization of Dcx, thereby regulating microtubule dynamics. Finally, Dcx overexpression rescues Abl1 knockdown-induced anatomic or functional defects. In summary, specific signaling by Abl1-Dcx in early-born interneurons facilitates the temporal development of the sGCL circuit to regulate innate olfactory functions, such as detection and sensitivity. © 2019 The Author(s) | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.title | Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.celrep.2019.12.004 | - |
dc.identifier.scopusid | 2-s2.0-85077311377 | - |
dc.identifier.bibliographicCitation | Cell Reports, v.30, no.1, pp.187 - 201 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | interneuron | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nervous system development | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | olfactory bulb | - |
dc.citation.endPage | 201 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 187 | - |
dc.citation.title | Cell Reports | - |
dc.citation.volume | 30 | - |
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