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DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release

Title
DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release
Translated Title
https://rims.dgist.ac.kr/auth/article/articlePopup.do#
Authors
Lim, Hye RyeongVo, Mai-TramKim, Dong JunLee, Unn HwaYoon, Jong HyukKim, Hyung-JunKim, JeongahKim, Sang RyongLee, Jun YeonYang, Chae HaKim, Hee YoungChoi, June-SeekKim, KijeongYang, EstherKim, HyunLee, SeongsooLee, Byung JuKim, KyungjinPark, Jeong WooHa, Chang Man
DGIST Authors
Lim, Hye Ryeong; Vo, Mai-Tram; Kim, Dong Jun; Lee, Unn Hwa; Yoon, Jong Hyuk; Kim, Hyung-Jun; Kim, Jeongah; Kim, Sang Ryong; Lee, Jun Yeon; Yang, Chae Ha; Kim, Hee Young; Choi, June-Seek; Kim, Kijeong; Yang, Esther; Kim, Hyun; Lee, Seongsoo; Lee, Byung Ju; Kim, Kyungjin; Park, Jeong Woo; Ha, Chang Man
Issue Date
2020-01
Citation
International Journal of Molecular Sciences, 21(1), 60
Type
Article
Article Type
Article
Author Keywords
Developmentally regulated GTP-binding protein 2 (DRG2)Dopamine releaseMotor deficiencyDopaminergic neuronsMotor coordinationStriatum
Keywords
SYSTEMPATHOPHYSIOLOGYOVEREXPRESSIONEXPRESSIONDEPLETIONINTERVALGENESMOUSE
ISSN
1661-6596
Abstract
Developmentally regulated GTP-binding protein 2 (DRG2) was first identified in the central nervous system of mice. However, the physiological function of DRG2 in the brain remains largely unknown. Here, we demonstrated that knocking out DRG2 impairs the function of dopamine neurons in mice. DRG2 was strongly expressed in the neurons of the dopaminergic system such as those in the striatum (Str), ventral tegmental area (VTA), and substantia nigra (SN), and on neuronal cell bodies in high-density regions such as the hippocampus (HIP), cerebellum, and cerebral cortex in the mouse brain. DRG2 knockout (KO) mice displayed defects in motor function in motor coordination and rotarod tests and increased anxiety. However, unexpectedly, DRG2 depletion did not affect the dopamine (DA) neuron population in the SN, Str, or VTA region or dopamine synthesis in the Str region. We further demonstrated that dopamine release was significantly diminished in the Str region of DRG2 KO mice and that treatment of DRG2 KO mice with l-3,4-dihydroxyphenylalanine (L-DOPA), a dopamine precursor, rescued the behavioral motor deficiency in DRG2 KO mice as observed with the rotarod test. This is the first report to identify DRG2 as a key regulator of dopamine release from dopamine neurons in the mouse brain. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/11407
DOI
10.3390/ijms21010060
Publisher
MDPI AG
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