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Translocator protein (TSPO): the new story of the old protein in neuroinflammation
- Translocator protein (TSPO): the new story of the old protein in neuroinflammation
- Lee, Younghwan; Park, Youngjin; Nam, Hyeri; Lee, Ji-Won; Yu, Seong-Woon
- DGIST Authors
- Yu, Seong-Woon
- Issue Date
- BMB Reports, 53(1), 20-27
- Article Type
- Author Keywords
- Microglia; Mitochondria; Neuroinflammation; Steroidogenesis; TSPO
- PERIPHERAL BENZODIAZEPINE-RECEPTOR; MICROGLIAL ACTIVATION; PERMEABILITY TRANSITION; LIGAND PK11195; PET; MITOCHONDRIA; STEROIDOGENESIS; INFLAMMATION; EXPRESSION; INCREASES
- Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain. Because of the close correlation of its expression level with neuropathology and therapeutic efficacies of several TSPO binding ligands under many neurological conditions, TSPO has been regarded as both biomarker and therapeutic target, and the biological functions of TSPO have been a major research focus. However, recent genetic studies with animal and cellular models revealed unexpected results contrary to the anticipated biological importance of TSPO and cast doubt on the action modes of the TSPO-binding drugs. In this review, we summarize recent controversial findings on the discrepancy between pharmacological and genetic studies of TSPO and suggest some future direction to understand this old and mysterious protein. [BMB Reports 2020; 53(1): 20-27].
- Related Researcher
Laboratory of Neuronal Cell Death
Molecular mechanisms of neuronal cell death and neurodegeneration
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- Department of Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles
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