Cited 12 time in webofscience Cited 13 time in scopus

Translocator protein (TSPO): the new story of the old protein in neuroinflammation

Title
Translocator protein (TSPO): the new story of the old protein in neuroinflammation
Authors
Lee, YounghwanPark, YoungjinNam, HyeriLee, Ji-WonYu, Seong-Woon
DGIST Authors
Yu, Seong-Woon
Issue Date
2020-01
Citation
BMB Reports, 53(1), 20-27
Type
Article
Article Type
Review
Author Keywords
MicrogliaMitochondriaNeuroinflammationSteroidogenesisTSPO
Keywords
PERIPHERAL BENZODIAZEPINE-RECEPTORMICROGLIAL ACTIVATIONPERMEABILITY TRANSITIONLIGAND PK11195PETMITOCHONDRIASTEROIDOGENESISINFLAMMATIONEXPRESSIONINCREASES
ISSN
1976-6696
Abstract
Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain. Because of the close correlation of its expression level with neuropathology and therapeutic efficacies of several TSPO binding ligands under many neurological conditions, TSPO has been regarded as both biomarker and therapeutic target, and the biological functions of TSPO have been a major research focus. However, recent genetic studies with animal and cellular models revealed unexpected results contrary to the anticipated biological importance of TSPO and cast doubt on the action modes of the TSPO-binding drugs. In this review, we summarize recent controversial findings on the discrepancy between pharmacological and genetic studies of TSPO and suggest some future direction to understand this old and mysterious protein. [BMB Reports 2020; 53(1): 20-27].
URI
http://hdl.handle.net/20.500.11750/11519
DOI
10.5483/bmbrep.2020.53.1.273
Publisher
생화학분자생물학회
Related Researcher
  • Author Yu, Seong-Woon Laboratory of Neuronal Cell Death
  • Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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