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dc.contributor.author Lee, Seungmin -
dc.contributor.author Kim, Jin-young -
dc.contributor.author Kim, Junyoung -
dc.contributor.author Hoshiar, Ali Kafash -
dc.contributor.author Park, Jongeon -
dc.contributor.author Lee, Sunkey -
dc.contributor.author Kim, Jonghyun -
dc.contributor.author Pane, Salvador -
dc.contributor.author Nelson, Bradley J. -
dc.contributor.author Choi, Hongsoo -
dc.date.accessioned 2020-03-20T10:54:28Z -
dc.date.available 2020-03-20T10:54:28Z -
dc.date.created 2020-03-20 -
dc.date.issued 2020-04 -
dc.identifier.issn 2192-2640 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/11575 -
dc.description.abstract A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s−1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim -
dc.language English -
dc.publisher John Wiley and Sons Ltd -
dc.title A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue -
dc.type Article -
dc.identifier.doi 10.1002/adhm.201901697 -
dc.identifier.wosid 000517782600001 -
dc.identifier.scopusid 2-s2.0-85081025968 -
dc.identifier.bibliographicCitation Advanced Healthcare Materials, v.9, no.7, pp.1901697 -
dc.description.isOpenAccess FALSE -
dc.subject.keywordAuthor fixation -
dc.subject.keywordAuthor magnetic manipulation -
dc.subject.keywordAuthor microrobots -
dc.subject.keywordAuthor targeted drug delivery -
dc.subject.keywordAuthor drug delivery -
dc.subject.keywordPlus ARTIFICIAL BACTERIAL FLAGELLA -
dc.subject.keywordPlus FABRICATION -
dc.subject.keywordPlus TIME -
dc.identifier.url https://onlinelibrary.wiley.com/cms/asset/120d5e8d-aba2-48f3-a53b-0f3f29bfe090/adhm202070019-gra-0001-m.jpg -
dc.citation.number 7 -
dc.citation.startPage 1901697 -
dc.citation.title Advanced Healthcare Materials -
dc.citation.volume 9 -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Engineering; Science & Technology - Other Topics; Materials Science -
dc.relation.journalWebOfScienceCategory Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials -
dc.type.docType Article -
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Appears in Collections:
Department of Robotics and Mechatronics Engineering Bio-Micro Robotics Lab 1. Journal Articles
Division of Biotechnology 1. Journal Articles

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