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Prefrontal functional connectivity analysis of cognitive decline for early diagnosis of mild cognitive impairment: A functional near-infrared spectroscopy study

Title
Prefrontal functional connectivity analysis of cognitive decline for early diagnosis of mild cognitive impairment: A functional near-infrared spectroscopy study
Authors
Yu, Jin-WooLim, Sung-HoKim, BominKim, EunhoKim, KyungsooPark, Sung KyuByun, Young SeokSakong, JoonChoi, Ji-Woong
DGIST Authors
Choi, Ji-Woong
Issue Date
2020-04
Citation
Biomedical Optics Express, 11(4), 1725-1741
Type
Article
Article Type
Article
Keywords
WORKING-MEMORYEXECUTIVE FUNCTIONSALZHEIMERS-DISEASEPERFORMANCEACTIVATIONCORTEXFNIRSMCIATTENTIONTISSUE
ISSN
2156-7085
Abstract
Cognitive decline (CD) is a major symptom of mild cognitive impairment (MCI). Patients with MCI have an increased likelihood of developing Alzheimer's disease (AD). Although a cure for AD is currently lacking, medication therapies and/or daily training in the early stage can alleviate disease progression and improve patients' quality of life. Accordingly, investigating CD-related biomarkers via brain imaging devices is crucial for early diagnosis. In particular, “portable” brain imaging devices enable frequent diagnostic checks as a routine clinical tool, and therefore increase the possibility of early AD diagnosis. This study aimed to comprehensively investigate functional connectivity (FC) in the prefrontal cortex measured by a portable functional near-infrared spectroscopy (fNIRS) device during a working memory (WM) task known as the delayed matching to sample (DMTS) task. Differences in prefrontal FC between healthy control (HC) (n = 23) and CD groups (n = 23) were examined. Intra-group analysis (one-sample t-test) revealed significantly greater prefrontal FC, especially left- and inter-hemispheric FC, in the CD group than in the HC. These observations could be due to a compensatory mechanism of the prefrontal cortex caused by hippocampal degeneration. Inter-group analysis (unpaired two-sample t-test) revealed significant intergroup differences in left- and inter-hemispheric FC. These attributes may serve as a novel biomarker for early detection of MCI. In addition, our findings imply that portable fNIRS devices covering the prefrontal cortex may be useful for early diagnosis of MCI. © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
URI
http://hdl.handle.net/20.500.11750/11665
DOI
10.1364/BOE.382197
Publisher
Optical Society of America
Related Researcher
  • Author Choi, Ji-Woong CSP(Communication and Signal Processing) Lab
  • Research Interests Communication System; Signal Processing; Communication Circuit Design; 생체 신호 통신 및 신호 처리; 뇌-기계 인터페이스(BMI); 차세대 교차계층 통신 및 신호 처리; 5G 모바일 통신
Files:
Collection:
Department of Information and Communication EngineeringCSP(Communication and Signal Processing) Lab1. Journal Articles


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