Cited 1 time in webofscience Cited 2 time in scopus

Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons

Title
Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons
Authors
Choe, Han KyoungCho, Jun
DGIST Authors
Choe, Han Kyoung
Issue Date
2020-03
Citation
International Journal of Molecular Sciences, 21(5), 1592
Type
Article
Article Type
Review
Author Keywords
translational controlactivity-dependent gene expressionmTOR signaling pathwaylocal translationphosphoTRAPribosome profilingRiboTagAutism spectrum disorderdepression
Keywords
MESSENGER-RNA TRANSLATIONLONG-TERM POTENTIATIONMENTAL-RETARDATION PROTEINFRAGILE-X-SYNDROMESYNAPTIC PLASTICITYMAMMALIAN TARGETSIGNALING PATHWAYIN-VIVOMEMORY CONSOLIDATIONMOLECULAR-MECHANISMS
ISSN
1661-6596
Abstract
Activity-dependent regulation of gene expression is critical in experience-mediated changes in the brain. Although less appreciated than transcriptional control, translational control is a crucial regulatory step of activity-mediated gene expression in physiological and pathological conditions. In the first part of this review, we overview evidence demonstrating the importance of translational controls under the context of synaptic plasticity as well as learning and memory. Then, molecular mechanisms underlying the translational control, including post-translational modifications of translation factors, mTOR signaling pathway, and local translation, are explored. We also summarize how activity-dependent translational regulation is associated with neurodevelopmental and psychiatric disorders, such as autism spectrum disorder and depression. In the second part, we highlight how recent application of high-throughput sequencing techniques has added insight into genome-wide studies on translational regulation of neuronal genes. Sequencing-based strategies to identify molecular signatures of the active neuronal population responding to a specific stimulus are discussed. Overall, this review aims to highlight the implication of translational control for neuronal gene regulation and functions of the brain and to suggest prospects provided by the leading-edge techniques to study yet-unappreciated translational regulation in the nervous system. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
URI
http://hdl.handle.net/20.500.11750/11693
DOI
10.3390/ijms21051592
Publisher
MDPI AG
Related Researcher
  • Author Choe, Han Kyoung Laboratory of Animal Behavior and Circadian rhythm
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Animal Behavior and Circadian rhythm1. Journal Articles


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