LAR RPTP, synaptic cell adhesion molecule , synaptic development, Drosophila
Synaptic connections occur when the nervous system begins to form throughout the life. During the synaptic development, the complexity and specificity of neuronal connection rely on various synaptic cell adhesion molecules. Neural circuits governing fundamental behavior like mobility is thought to have stereotyped neural network, forming tight bonds. Here, I characterized one of the evolutionarily conserved synaptic CAMs, LAR-RPTP or DLAR in Drosophila may be responsible for generating mobility control. Furthermore, I characterize spatiotemporal properties of DLAR, suggesting its function may be crucial during synaptic establishment at motor neuron. Taken together, these results suggest that DLAR may have contribu tion to formation of mobility behavior in Drosophila.
Table Of Contents
Abstract i List of contents ii List of figures iii
Ⅰ. Introduction 1 II. Materials and Methods 4 III. Results 3.1 DLAR plays an important role in generating mobility control of Drosophila 8 3.2 Functional DLAR is plays its role during synaptic establishment 9 3.3 DLAR functionality have positive correlation between NMJ morphology 10 IV. Discussion 26 V. References 28 VI. Summary in Korean 30