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Characterization of spatiotemporal properties of LAR-RPTP and its effect on Drosophila melanogaster mobility

Title
Characterization of spatiotemporal properties of LAR-RPTP and its effect on Drosophila melanogaster mobility
Translated Title
LAR-RPTP의 시공간적 특성 규명 및 노랑 초파리의 운동성에 미치는 영향
Authors
Kyung Min Kim
DGIST Authors
Kim, Kyung Min; Lee, Sung Bae; Kim, Ho Min
Advisor(s)
이성배
Co-Advisor(s)
Ho Min Kim
Issue Date
2020
Available Date
2020-06-06
Degree Date
2020-02
Type
Thesis
Description
LAR RPTP, synaptic cell adhesion molecule , synaptic development, Drosophila
Abstract
Synaptic connections occur when the nervous system begins to form throughout the life. During the synaptic development, the complexity and specificity of neuronal connection rely on various synaptic cell adhesion molecules. Neural circuits governing fundamental behavior like mobility is thought to have stereotyped neural network, forming tight bonds. Here, I characterized one of the evolutionarily conserved synaptic CAMs, LAR-RPTP or DLAR in Drosophila may be responsible for generating mobility control. Furthermore, I characterize spatiotemporal properties of DLAR, suggesting its function may be crucial during synaptic establishment at motor neuron. Taken together, these results suggest that DLAR may have contribu tion to formation of mobility behavior in Drosophila.
Table Of Contents
Abstract i List of contents ii List of figures iii Ⅰ. Introduction 1 II. Materials and Methods 4 III. Results 3.1 DLAR plays an important role in generating mobility control of Drosophila 8 3.2 Functional DLAR is plays its role during synaptic establishment 9 3.3 DLAR functionality have positive correlation between NMJ morphology 10 IV. Discussion 26 V. References 28 VI. Summary in Korean 30
URI
http://dgist.dcollection.net/common/orgView/200000286819
http://hdl.handle.net/20.500.11750/11899
DOI
10.22677/Theses.200000286819
Degree
Master
Department
Brain and Cognitive Sciences
University
DGIST
Related Researcher
  • Author Lee, Sung Bae Laboratory of Neurodegenerative Diseases and Aging
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
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Collection:
Department of Brain and Cognitive SciencesThesesMaster


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