Characterization of spatiotemporal properties of LAR-RPTP and its effect on Drosophila melanogaster mobility

Abstract

Synaptic connections occur when the nervous system begins to form throughout the life. During the synaptic development, the complexity and specificity of neuronal connection rely on various synaptic cell adhesion molecules. Neural circuits governing fundamental behavior like mobility is thought to have stereotyped neural network, forming tight bonds. Here, I characterized one of the evolutionarily conserved synaptic CAMs, LAR-RPTP or DLAR in Drosophila may be responsible for generating mobility control. Furthermore, I characterize spatiotemporal properties of DLAR, suggesting its function may be crucial during synaptic establishment at motor neuron. Taken together, these results suggest that DLAR may have contribu tion to formation of mobility behavior in Drosophila.