Cited 3 time in webofscience Cited 4 time in scopus

Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses

Title
Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses
Authors
Han, Kyung AhLee, Hee-YoonLim, DongseokShin, JungsuYoon, Taek HanLi, XinranUm, Ji WonChoi, Se-YoungKo, Jaewon
DGIST Authors
Um, Ji WonKo, Jaewon
Issue Date
2020-06
Citation
Molecular Brain, 13(1), 94
Type
Article
Article Type
Article
Author Keywords
PTP deltaPTP sigmaLAR-RPTPSynapse maintenanceSynaptic transmissionSynaptic adhesion
Keywords
PTP-SIGMALAR-RPTPSCOMPLEXES
ISSN
1756-6606
Abstract
Members of the leukocyte common antigen-related receptor protein tyrosine phosphatase (LAR-RPTP) family, comprising PTPσ, PTPδ and LAR, are key hubs for presynaptic assembly and differentiation in vertebrate neurons. However, roles of individual LAR-RPTP members have not been investigated using member-specific conditional knockout mice. Here, we show that loss of PTPδ had no overt effect on synapse development in mouse cultured hippocampal neurons. Moreover, loss of PTPδ in presynaptic CA1 hippocampal neurons did not influence neurotransmitter release in subicular pyramidal neurons, suggesting that PTPδ is not critical for presynaptic function in vivo. Our results demonstrate that PTPδ is not essential for synapse maintenance or transmission, at least in the mouse hippocampus, and underscore the importance of using sophisticated genetic approaches to confirm the roles of synaptic proteins.
URI
http://hdl.handle.net/20.500.11750/12040
DOI
10.1186/s13041-020-00629-x
Publisher
BioMed Central
Related Researcher
  • Author Ko, Jaewon Laboratory of Synapse Formation and Function
  • Research Interests Synapse Formation and Function; Neural Circuits; 뇌질환; animal model
Files:
Collection:
Department of Brain and Cognitive SciencesSynapse Disorder Laboratory1. Journal Articles
Department of Brain and Cognitive SciencesLaboratory of Synapse Formation and Function1. Journal Articles


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