엄지원
Um, Ji Won학력
- 2004 ~ 2008연세대학교 박사
- 2002 ~ 2004연세대학교 석사
- 1998 ~ 2002연세대학교 학사
경력
- 2015 ~ 2017연세대학교 의과대학 / 조교수
- 2013 ~ 2015연세대학교 / 연구교수
- 2009 ~ 2013예일대학교 의과대학 / 박사후연구원
- 2008 ~ 2009연세대학교 생물학과 / 박사후연구원
수상실적
- 2022총장표창
연구실 소개
- Synapse Disorder Laboratory
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The goal of my research is to understand the pathophysiological mechanisms underlying neurological diseases (i.e. Alzheimer‘s disease, autism spectrum disorders, or schizophrenia) that are caused by various forms of synaptic dysfunctions. To better understand how synaptic genes associated with those neurological disorders impact brain functions in the synaptic, cellular and systemic levels, we have aspired to alter the activity of specific neuronal circuits and to evaluate the consequences on pathology, network activity, and animal behaviors. To achieve our research goals, we are using a combination of protein biochemistry, cell imaging, electrophysiology and mouse genetics. Three research projects are currently ongoing in my laboratory. First, we are investigating how mutations of synaptic genes observed in patients with autism spectrum disorders, schizophrenia, or epilepsy alter various aspects of synaptic functions. Second, we are studying molecular and cellular mechanisms through which synapses are formed and eliminated in normal development and/or pathological conditions. Third, we are exploring the role of specific synaptic signaling proteins in maintaining the excitation-to-inhibition balance at synapses and associated neural circuits.
- "EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2", Progress in Neurobiology, v.250
- "The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions", Cell Reports, v.44, no.5
- "Multifarious astrocyte–neuron dialog in shaping neural circuit architecture", Trends in Cell Biology, v.35, no.1, pp.74 - 87
- "MDGAs perform activity- dependent synapse type- specific suppression via distinct extracellular mechanisms", Proceedings of the National Academy of Sciences of the United States of America, v.121, no.26
- "Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons", Nature Communications, v.15, no.1, pp.1624
연구분야
국가과학기술표준분류
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LA. 생명과학
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LA03. 발생/신경생물학
LA0304. 신경 생화학/생리학
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LA. 생명과학
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LA03. 발생/신경생물학
LA0305. 신경질환생물학
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12대 국가전략기술 분야
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첨단바이오
유전자·세포 치료