엄지원
Um, Ji Won학력
- 2004 ~ 2008연세대학교 박사
- 2002 ~ 2004연세대학교 석사
- 1998 ~ 2002연세대학교 학사
경력
- 2015 ~ 2017연세대학교 의과대학 / 조교수
- 2013 ~ 2015연세대학교 / 연구교수
- 2009 ~ 2013예일대학교 의과대학 / 박사후연구원
- 2008 ~ 2009연세대학교 생물학과 / 박사후연구원
수상실적
- 2022총장표창
연구실 소개
- Synapse Disorder Laboratory
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The goal of my research is to understand the pathophysiological mechanisms underlying neurological diseases (i.e. Alzheimer‘s disease, autism spectrum disorders, or schizophrenia) that are caused by various forms of synaptic dysfunctions. To better understand how synaptic genes associated with those neurological disorders impact brain functions in the synaptic, cellular and systemic levels, we have aspired to alter the activity of specific neuronal circuits and to evaluate the consequences on pathology, network activity, and animal behaviors. To achieve our research goals, we are using a combination of protein biochemistry, cell imaging, electrophysiology and mouse genetics. Three research projects are currently ongoing in my laboratory. First, we are investigating how mutations of synaptic genes observed in patients with autism spectrum disorders, schizophrenia, or epilepsy alter various aspects of synaptic functions. Second, we are studying molecular and cellular mechanisms through which synapses are formed and eliminated in normal development and/or pathological conditions. Third, we are exploring the role of specific synaptic signaling proteins in maintaining the excitation-to-inhibition balance at synapses and associated neural circuits.
- "EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2", Progress in Neurobiology, v.250
- "The NLRP3 inflammasome in microglia regulates repetitive behavior by modulating NMDA glutamate receptor functions", Cell Reports, v.44, no.5
- "Multifarious astrocyte–neuron dialog in shaping neural circuit architecture", Trends in Cell Biology, v.35, no.1, pp.74 - 87
- "MDGAs perform activity- dependent synapse type- specific suppression via distinct extracellular mechanisms", Proceedings of the National Academy of Sciences of the United States of America, v.121, no.26
- "Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons", Nature Communications, v.15, no.1, pp.1624
연구 뉴스
- Uncovering the Secret of MDGA* Protein, the Hidden Conductor of Neuronal Connections! 2025-01-21
- 신경세포 연결의 숨은 지휘자, MDGA* 단백질의 비밀을 밝혀내다! 2025-01-21
- DGIST professors Ji Won Um and Jaewon Ko published a review paper compiling methods of intercellular communication in the brain 2025-01-21
- DGIST 엄지원·고재원 교수팀, 뇌 속 세포들 간 소통방법을 집대성한 종설 논문 발표 2025-01-21
- Revelation of the molecular code for constructing brain neural circuits With identification of the characteristics of excitatory synapses and memory cognition regulation 2025-01-21
연구분야
미래유망 신기술(6T)
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20.
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201.
20115. 뇌신경과학연구
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국가과학기술표준분류
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LA. 생명과학
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LA03. 발생/신경생물학
LA0304. 신경 생화학/생리학
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LA. 생명과학
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LA03. 발생/신경생물학
LA0305. 신경질환생물학
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OA. 뇌과학
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OA01. 뇌신경생물
OA0103. 시냅스 및 신경신호전달
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12대 국가전략기술 분야
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첨단바이오
유전자·세포 치료