Cited 8 time in webofscience Cited 7 time in scopus

ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis

Title
ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis
Authors
Li, ZhonghaiKim, Jin HeeKim, JeongsikLyu, Jae IlZhang, YiGuo, HongweiNam, Hong GilWoo, Hye Ryun
DGIST Authors
Nam, Hong GilWoo, Hye Ryun
Issue Date
2020-07
Citation
New Phytologist, 227(2), 473-484
Type
Article
Article Type
Article
Author Keywords
Arabidopsis thalianaATMDNA repairdouble-strand breakshistone methylationleaf senescence
Keywords
HISTONE MODIFICATIONSGENOME STABILITYDAMAGEREPAIRMETHYLATIONRESPONSESMECHANISMSEXPRESSIONLETHALITYPATHWAYS
ISSN
0028-646X
Abstract
All living organisms are unavoidably exposed to various endogenous and environmental stresses that trigger potentially fatal DNA damage, including double-strand breaks (DSBs). Although a growing body of evidence indicates that DNA damage is one of the prime drivers of aging in animals, little is known regarding the importance of DNA damage and its repair on lifespan control in plants. We found that the level of DSBs increases but DNA repair efficiency decreases as Arabidopsis leaves age. Generation of DSBs by inducible expression of I-PpoI leads to premature senescence phenotypes. We examined the senescence phenotypes in the loss-of-function mutants for 13 key components of the DNA repair pathway and found that deficiency in ATAXIA TELANGIECTASIA MUTATED (ATM), the chief transducer of the DSB signal, results in premature senescence in Arabidopsis. ATM represses DSB-induced expression of senescence-associated genes, including the genes encoding the WRKY and NAC transcription factors, central components of the leaf senescence process, via modulation of histone lysine methylation. Our work highlights the significance of ATM in the control of leaf senescence and has significant implications for the conservation of aging mechanisms in animals and plants. © 2020 The Authors. New Phytologist © 2020 New Phytologist Trust
URI
http://hdl.handle.net/20.500.11750/12058
DOI
10.1111/nph.16535
Publisher
Blackwell Publishing Inc.
Related Researcher
  • Author Nam, Hong Gil CBRG(Complex Biology Research Group)
  • Research Interests Plant Aging and Life History; Systems Biology; Complexbiology; Comparative Aging Research
Files:
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Collection:
Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
Department of New BiologyLab of Plant Molecular Communication1. Journal Articles


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