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Autophagy as a decisive process for cell death

Title
Autophagy as a decisive process for cell death
Authors
Jung, SeongheeJeong, HyeonjeongYu, Seong-Woon
DGIST Authors
Jung, Seonghee; Jeong, Hyeonjeong; Yu, Seong-Woon
Issue Date
2020-06
Citation
Experimental and Molecular Medicine, 52(6), 921-930
Type
Article
Article Type
Review
Keywords
NEURAL STEM-CELLSSTRESSNEUROGENESISAPOPTOSISPROTEINSDISEASENECROPTOSISMECHANISMSINDUCTIONMEDIATOR
ISSN
1226-3613
Abstract
Autophagy is an intracellular catabolic pathway in which cellular constituents are engulfed by autophagosomes and degraded upon autophagosome fusion with lysosomes. Autophagy serves as a major cytoprotective process by maintaining cellular homeostasis and recycling cytoplasmic contents. However, emerging evidence suggests that autophagy is a primary mechanism of cell death (autophagic cell death, ACD) and implicates ACD in several aspects of mammalian physiology, including tumor suppression and psychological disorders. However, little is known about the physiological roles and molecular mechanisms of ACD. In this review, we document examples of ACD and discuss recent progress in our understanding of its molecular mechanisms. © 2020, The Author(s).
URI
http://hdl.handle.net/20.500.11750/12089
DOI
10.1038/s12276-020-0455-4
Publisher
Springer Nature
Related Researcher
  • Author Yu, Seong-Woon Laboratory of Neuronal Cell Death
  • Research Interests Molecular mechanisms of neuronal cell death and neurodegeneration
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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