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Ultradian Rhythms in the Hypothalamic Arcuate Nucleus Kisspeptin Neurons and Developmental Processes

Title
Ultradian Rhythms in the Hypothalamic Arcuate Nucleus Kisspeptin Neurons and Developmental Processes
Authors
Kim, DoyeonChoe, Han KyoungKim, Kyungjin
DGIST Authors
Choe, Han Kyoung
Issue Date
2020-07
Citation
Molecules and Cells, 43(7), 600-606
Type
Article
Article Type
Review
Author Keywords
calcium oscillationdevelopmentkisspeptin reproductionultradian rhythm
Keywords
CIRCADIAN TIMING SYSTEMGENE-EXPRESSIONNEUROKININ BOSCILLATIONSMODULATIONSECRETIONRESPONSESDYNAMICSPUBERTYPROTEIN
ISSN
0219-1032
Abstract
Numerous physiological processes in nature have multiple oscillations within 24 h, that is, ultradian rhythms. Compared to the circadian rhythm, which has a period of approximately one day, these short oscillations range from seconds to hours, and the mechanisms underlying ultradian rhythms remain largely unknown. This review aims to explore and emphasize the implications of ultradian rhythms and their underlying regulations. Reproduction and developmental processes show ultradian rhythms, and these physiological systems can be regulated by short biological rhythms. Specifically, we recently uncovered synchronized calcium oscillations in the organotypic culture of hypothalamic arcuate nucleus (ARN) kisspeptin neurons that regulate reproduction. Synchronized calcium oscillations were dependent on voltage-gated ion channel-mediated action potentials and were repressed by chemogenetic inhibition, suggesting that the network within the ARN and between the kisspeptin population mediates the oscillation. This minireview describes that ultradian rhythms are a general theme that underlies biological features, with special reference to calcium oscillations in the hypothalamic ARN from a developmental perspective. We expect that more attention to these oscillations might provide insight into physiological or developmental mechanisms, since many oscillatory features in nature still remain to be explored.
URI
http://hdl.handle.net/20.500.11750/12339
DOI
10.14348/molcells.2020.0066
Publisher
The Korean Society for Molecular and Cellular Biology
Related Researcher
  • Author Choe, Han Kyoung Laboratory of Animal Behavior and Circadian rhythm
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesLaboratory of Animal Behavior and Circadian rhythm1. Journal Articles


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