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Longitudinal profiling of oligomeric A beta in human nasal discharge reflecting cognitive decline in probable Alzheimer's disease

Title
Longitudinal profiling of oligomeric A beta in human nasal discharge reflecting cognitive decline in probable Alzheimer's disease
Authors
Yoo, Seung JunSon, GowoonBae, JisubKim, So YeunYoo, Yong KyoungPark, DongsungBaek, Seung YeopChang, Keun-ASuh, Yoo-HunLee, Yeong-BaeHwang, Kyo SeonKim, YoungSooMoon, Cheil
DGIST Authors
Moon, Cheil
Issue Date
2020-07
Citation
Scientific Reports, 10(1), 11234
Type
Article
Article Type
Article
Keywords
AMYLOID-BETAOLFACTORY DYSFUNCTIONNATIONAL INSTITUTEASSOCIATION WORKGROUPSDIAGNOSTIC GUIDELINESCLINICAL-TRIALSDEMENTIAPROTEINIMPAIRMENTBIOMARKERS
ISSN
2045-2322
Abstract
Despite clinical evidence indicating a close relationship between olfactory dysfunction and Alzheimer’s disease (AD), further investigations are warranted to determine the diagnostic potential of nasal surrogate biomarkers for AD. In this study, we first identified soluble amyloid-β (Aβ), the key biomarker of AD, in patient nasal discharge using proteomic analysis. Then, we profiled the significant differences in Aβ oligomers level between patient groups with mild or moderate cognitive decline (n = 39) and an age-matched normal control group (n = 21) by immunoblot analysis and comparing the levels of Aβ by a self-standard method with interdigitated microelectrode sensor systems. All subjects received the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and the Global Deterioration Scale (GDS) for grouping. We observed higher levels of Aβ oligomers in probable AD subjects with lower MMSE, higher CDR, and higher GDS compared to the normal control group. Moreover, mild and moderate subject groups could be distinguished based on the increased composition of two oligomers, 12-mer Aβ*56 and 15-mer AβO, respectively. The longitudinal cohort study confirmed that the cognitive decline of mild AD patients with high nasal discharge Aβ*56 levels advanced to the moderate stage within three years. Our clinical evidence strongly supports the view that the presence of oligomeric Aβ proteins in nasal discharge is a potential surrogate biomarker of AD and an indicator of cognitive decline progression. © 2020, The Author(s).
URI
http://hdl.handle.net/20.500.11750/12353
DOI
10.1038/s41598-020-68148-2
Publisher
Nature Publishing Group
Related Researcher
  • Author Moon, Cheil Laboratory of Chemical Senses
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
Collection:
Department of Brain and Cognitive SciencesLaboratory of Chemical Senses1. Journal Articles


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