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A Light Illumination Enhancement Device for Photoacoustic Imaging: In Vivo Animal Study
- A Light Illumination Enhancement Device for Photoacoustic Imaging: In Vivo Animal Study
- Yu, Jaesok; Schuman, Joel S.; Lee, Jung-Kun; Lee, Sang-Goo; Chang, Jin Ho; Kim, Kang
- DGIST Authors
- Yu, Jaesok; Chang, Jin Ho
- Issue Date
- IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 64(8), 1205-1211
- Article Type
- Author Keywords
- light catcher; Laser illumination scheme; optical scattering; photoacoustic (PA) imaging; tumor imaging
- Photoacoustic (PA) imaging detects acoustic signals generated by thermal expansion of a light-excited tissue or contrast agents. PA signal amplitude and image quality directly depend on the light fluence at the target depth. With conventional PA imaging systems, approximately 30% energy of incident light at the near-infrared region would be lost due to reflection on the skin surface. Such light loss directly leads to a reduction of PA signal and image quality. A new light delivery scheme that collects and redistributes reflected light energy was recently suggested, which is called the light catcher. In our previous study, proof of concept using a finite-element simulation model was shown and a laboratory-built prototype of the light catcher was applied on tissue-mimicking phantoms. In this paper, we present an elaborate prototype of a high-frequency PA probe with the light catcher fabricated using 3-D printing technology, which is conformal to a subcutaneous tumor in mice. The in vivo usefulness of the developed prototype was evaluated in a mouse tumor model. Equipped with the light catcher, PA signal amplitude from the clinical photosensitizer injected into the mouse tumor was enhanced by 33.7%, which is approximately equivalent to the percent light loss due to reflection on the skin. © 1986-2012 IEEE.
- Institute of Electrical and Electronics Engineers
- Related Researcher
Chang, Jin Ho
Medical Acoustic Fusion Innovation Lab.
Biomedical Imaging, Signal and Image Processing, Ultrasound Imaging System, Ultrasound Transducer, Photoacoustic Imaging
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