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A Light Illumination Enhancement Device for Photoacoustic Imaging: In Vivo Animal Study

A Light Illumination Enhancement Device for Photoacoustic Imaging: In Vivo Animal Study
Yu, JaesokSchuman, Joel S.Lee, Jung-KunLee, Sang-GooChang, Jin HoKim, Kang
DGIST Authors
Yu, JaesokChang, Jin Ho
Issued Date
Article Type
Author Keywords
light catcherLaser illumination schemeoptical scatteringphotoacoustic (PA) imagingtumor imaging
Photoacoustic (PA) imaging detects acoustic signals generated by thermal expansion of a light-excited tissue or contrast agents. PA signal amplitude and image quality directly depend on the light fluence at the target depth. With conventional PA imaging systems, approximately 30% energy of incident light at the near-infrared region would be lost due to reflection on the skin surface. Such light loss directly leads to a reduction of PA signal and image quality. A new light delivery scheme that collects and redistributes reflected light energy was recently suggested, which is called the light catcher. In our previous study, proof of concept using a finite-element simulation model was shown and a laboratory-built prototype of the light catcher was applied on tissue-mimicking phantoms. In this paper, we present an elaborate prototype of a high-frequency PA probe with the light catcher fabricated using 3-D printing technology, which is conformal to a subcutaneous tumor in mice. The in vivo usefulness of the developed prototype was evaluated in a mouse tumor model. Equipped with the light catcher, PA signal amplitude from the clinical photosensitizer injected into the mouse tumor was enhanced by 33.7%, which is approximately equivalent to the percent light loss due to reflection on the skin. © 1986-2012 IEEE.
Institute of Electrical and Electronics Engineers
Related Researcher
  • 유재석 Yu, Jaesok 로봇및기계전자공학과
  • Research Interests Biomedical ultrasound/photoacoustic imaging and therapeutics; Medical image processing; Machine learning-based diagnosis and signal processing; Nano-theranostic platform
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Appears in Collections:
Department of Electrical Engineering and Computer Science Medical Acoustic Fusion Innovation Lab. 1. Journal Articles
Department of Robotics and Mechatronics Engineering Advanced Ultrasound Research Laboratory 1. Journal Articles


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