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Thermoplasmonic Optical Fiber for Localized Neural Stimulation
- Thermoplasmonic Optical Fiber for Localized Neural Stimulation
- Kang, Hongki; Hong, Woongki; An, Yujin; Yoo, Sangjin; Kwon, Hyuk-Jun; Nam, Yoonkey
- DGIST Authors
- Kang, Hongki; Kwon, Hyuk-Jun
- Issue Date
- ACS Nano, 14(9), 11406-11419
- Article Type
- Author Keywords
- optical neural stimulation; neuromodulation; thermoplasmonics; photothermal effect; optical fiber; gold nanorod; microelectrode array
- Thermoplasmonic effect-based neural stimulation has been suggested as an alternative optical neural stimulation technology without genetic modification. Integration of near-infrared light with plasmonic gold nanoparticles has been demonstrated as a neuromodulation tool on in vitro neuronal network models. In order to further test the validity of the thermoplasmonic neural stimulation across multiple biological models (in vitro, ex vivo, and in vivo) avoiding genetic modification in optical neuromodulation, versatile engineering approaches to apply the thermoplasmonic effect would be required. In this work, we developed a gold nanorod attached optical fiber technology for the localized neural stimulation based on a thermoplasmonic effect. A simple fabrication process was developed for efficient nanoparticle coating on commercial optical fibers. The thermoplasmonic optical fiber proved that it can locally modulate the neural activity in vitro. Lastly, we simulated the spatiotemporal temperature change by the thermoplasmonic optical fiber and analyzed its applicability to in vivo animal models.
- American Chemical Society
- Related Researcher
Advanced Electronic Devices Research Group(AEDRG) - Kwon Lab.
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- Department of Information and Communication EngineeringAdvanced Electronic Devices Research Group(AEDRG) - Kang Lab.1. Journal Articles
Department of Information and Communication EngineeringAdvanced Electronic Devices Research Group(AEDRG) - Kwon Lab.1. Journal Articles
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