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Thermoplasmonic Optical Fiber for Localized Neural Stimulation

Title
Thermoplasmonic Optical Fiber for Localized Neural Stimulation
Authors
Kang, HongkiHong, WoongkiAn, YujinYoo, SangjinKwon, Hyuk-JunNam, Yoonkey
DGIST Authors
Kang, HongkiKwon, Hyuk-Jun
Issue Date
2020-09
Citation
ACS Nano, 14(9), 11406-11419
Type
Article
Article Type
Article
Author Keywords
optical neural stimulationneuromodulationthermoplasmonicsphotothermal effectoptical fibergold nanorodmicroelectrode array
ISSN
1936-0851
Abstract
Thermoplasmonic effect-based neural stimulation has been suggested as an alternative optical neural stimulation technology without genetic modification. Integration of near-infrared light with plasmonic gold nanoparticles has been demonstrated as a neuromodulation tool on in vitro neuronal network models. In order to further test the validity of the thermoplasmonic neural stimulation across multiple biological models (in vitro, ex vivo, and in vivo) avoiding genetic modification in optical neuromodulation, versatile engineering approaches to apply the thermoplasmonic effect would be required. In this work, we developed a gold nanorod attached optical fiber technology for the localized neural stimulation based on a thermoplasmonic effect. A simple fabrication process was developed for efficient nanoparticle coating on commercial optical fibers. The thermoplasmonic optical fiber proved that it can locally modulate the neural activity in vitro. Lastly, we simulated the spatiotemporal temperature change by the thermoplasmonic optical fiber and analyzed its applicability to in vivo animal models.
URI
http://hdl.handle.net/20.500.11750/12413
DOI
10.1021/acsnano.0c03703
Publisher
American Chemical Society
Related Researcher
  • Author Kwon, Hyuk-Jun Advanced Electronic Devices Research Group(AEDRG) - Kwon Lab.
  • Research Interests
Files:
There are no files associated with this item.
Collection:
Department of Information and Communication EngineeringAdvanced Electronic Devices Research Group(AEDRG) - Kang Lab.1. Journal Articles
Department of Information and Communication EngineeringAdvanced Electronic Devices Research Group(AEDRG) - Kwon Lab.1. Journal Articles


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