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Ab‑interno surgical technique for the implantation of a wireless subretinal prosthesis in mini‑pigs

Title
Ab‑interno surgical technique for the implantation of a wireless subretinal prosthesis in mini‑pigs
Authors
Choi, Kwang‑EonAhn, Vu Thi QueSeo, Hee WonKim, NamjuKim, SoheeKim, Seong‑Woo
DGIST Authors
Choi, Kwang‑Eon; Ahn, Vu Thi Que; Seo, Hee Won; Kim, Namju; Kim, Sohee; Kim, Seong‑Woo
Issue Date
2020-10
Citation
Scientific Reports, 10(1), 18507
Type
Article
Article Type
Article
Keywords
POLYIMIDE FILM ELECTRODESLONG-TERM IMPLANTATIONVISUAL PROSTHESISRETINAL PROSTHESISELECTRICAL-STIMULATIONVISIONFEASIBILITYTHICKNESSPROGRESSSURGERY
ISSN
2045-2322
Abstract
We sought to describe the surgical techniques required in the ab-interno method to implant subretinal prostheses in mini-pigs and suggest tips to facilitate optimal outcomes. During vitrectomy, the use of valved trocar cannulas was essential to stabilize the detached retina and implanted chip. As a first step in retinal detachment, a 23-gauge cannula with very small amount of viscoelastic material was used to establish the retinal hole and promote retinal detachment. Then, balanced salt solution was applied to increase the retinal detachment and diathermy was used to make opening for subretinal prosthesis. For easy positioning of the subretinal prosthesis, a curved laser probe was adopted when handling the subretinal prosthesis under the retina. After surgery, the sclerotomy sites were tightly sutured to prevent silicone oil leakage. Without special equipment, such as a 41-gauge tip, retinal detachment could be induced easily, while the prosthesis was also successfully inserted and manipulated under the retina without an iatrogenic retinal tear. Two weeks after the operation, the oil fully occupied the intraocular volume without leakage. The subretinal prosthesis remained stable without complication. Understanding the principle of the ab-interno method and considering several tips for improving surgical access may help to enhance surgical success rates of subretinal prostheses implantation. © 2020, The Author(s).
URI
http://hdl.handle.net/20.500.11750/12487
DOI
10.1038/s41598-020-75579-4
Publisher
Nature Research
Related Researcher
  • Author Kim, Sohee Neural Interfaces & MicroSystems Lab
  • Research Interests Neural interface; Brain interface; Bio MEMS; Soft MEMS; Stretchable electronics; Zebrafish electrophysiology
Files:
Collection:
Department of Robotics and Mechatronics EngineeringNeural Interfaces & MicroSystems Lab1. Journal Articles


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