Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Chung, Chang Geon | - |
dc.contributor.author | Park, Sung Soon | - |
dc.contributor.author | Park, Jeong Hyang | - |
dc.contributor.author | Lee, Sung Bae | - |
dc.date.accessioned | 2020-12-08T04:53:36Z | - |
dc.date.available | 2020-12-08T04:53:36Z | - |
dc.date.created | 2020-11-09 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | Frontiers in Cellular Neuroscience, v.14, pp.556461 | - |
dc.identifier.issn | 1662-5102 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12520 | - |
dc.description.abstract | Due to their enormous surface area compared to other cell types, neurons face unique challenges in properly handling supply and retrieval of the plasma membrane (PM)—a process termed PM turnover—in their distal areas. Because of the length and extensiveness of dendritic branches in neurons, the transport of materials needed for PM turnover from soma to distal dendrites will be inefficient and quite burdensome for somatic organelles. To meet local demands, PM turnover in dendrites most likely requires local cellular machinery, such as dendritic endocytic and secretory systems, dysregulation of which may result in dendritic pathology observed in various neurodegenerative diseases (NDs). Supporting this notion, a growing body of literature provides evidence to suggest the pathogenic contribution of dysregulated PM turnover to dendritic pathology in certain NDs. In this article, we present our perspective view that impaired dendritic endocytic and secretory systems may contribute to dendritic pathology by encumbering PM turnover in NDs. © 2020 Chung, Park, Park and Lee. | - |
dc.language | English | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Dysregulated Plasma Membrane Turnover Underlying Dendritic Pathology in Neurodegenerative Diseases | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fncel.2020.556461 | - |
dc.identifier.wosid | 000580637500001 | - |
dc.identifier.scopusid | 2-s2.0-85094146741 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Frontiers in Cellular Neuroscience | - |
dc.contributor.nonIdAuthor | Chung, Chang Geon | - |
dc.contributor.nonIdAuthor | Park, Sung Soon | - |
dc.contributor.nonIdAuthor | Park, Jeong Hyang | - |
dc.identifier.citationVolume | 14 | - |
dc.identifier.citationStartPage | 556461 | - |
dc.identifier.citationTitle | Frontiers in Cellular Neuroscience | - |
dc.type.journalArticle | Review | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | plasma membrane turnover | - |
dc.subject.keywordAuthor | dendritic pathology | - |
dc.subject.keywordAuthor | neurodegenerative diseases | - |
dc.subject.keywordAuthor | Rab GTPases | - |
dc.subject.keywordAuthor | dendritic secretory pathway | - |
dc.subject.keywordAuthor | dendritic endocytic pathway | - |
dc.subject.keywordPlus | CLATHRIN-COATED VESICLES | - |
dc.subject.keywordPlus | ER-EXIT SITES | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | RAB GTPASES | - |
dc.subject.keywordPlus | SPINE LOSS | - |
dc.subject.keywordPlus | SECRETORY TRAFFICKING | - |
dc.subject.keywordPlus | ENDOSOMAL TRAFFICKING | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | AMPA RECEPTORS | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.contributor.affiliatedAuthor | Chung, Chang Geon | - |
dc.contributor.affiliatedAuthor | Park, Sung Soon | - |
dc.contributor.affiliatedAuthor | Park, Jeong Hyang | - |
dc.contributor.affiliatedAuthor | Lee, Sung Bae | - |