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Gold-Nanoparticle Layer Substrate Assisted Transmission-Mode Laser Desorption for Atmospheric Pressure Mass Spectrometry Imaging

Title
Gold-Nanoparticle Layer Substrate Assisted Transmission-Mode Laser Desorption for Atmospheric Pressure Mass Spectrometry Imaging
Authors
Kim, Jae YoungLim, HeejinSun Young LeeGwanjin, LeeLim, Dong-KwonMoon, DaeWonSong, Cheol
DGIST Authors
Kim, Jae Young; Song, Cheol
Issue Date
2020-10
Citation
Science of Advanced Materials, 12(10), 1517-1523
Type
Article
Article Type
Article
Author Keywords
Tissue ImagingMass Spectrometry ImagingGold-Nanoparticle Layer SubstrateLaser DesorptionAmbient Mass Spectrometry
Keywords
ELECTROSPRAY-IONIZATIONION-SOURCEIN-VIVODESORPTION/IONIZATION
ISSN
1947-2935
Abstract
We demonstrate continuous-wave laser-based ambient mass spectrometry imaging with the use of a gold-nanoparticle layer substrate. When a fresh tissue slice is placed on a gold-nanoparticle layer substrate and irradiated with a 532-nm continuous-wave laser, the transmission-mode laser configuration provides precise desorption performance to facilitate mass spectrometry imaging. The subsequent ionization process with non-thermal atmospheric pressure plasma jets generates sufficient amounts of molecular ions. By using this method, micrometer-spatial-resolution mass spectrometry imaging of humid tissues can be obtained. The gold-nanoparticle layer substrates can be prepared and stored in advance of the experiment, resulting in simplified specimen preparation and an advantage in faster preparing of fresh tissue specimen for analysis.
URI
http://hdl.handle.net/20.500.11750/12588
DOI
10.1166/sam.2020.3792
Publisher
American Scientific Publishers
Related Researcher
  • Author Song, Cheol Intelligent Bio-OptoMechatronics Lab
  • Research Interests Handheld medical robotics; Smart robotic microsurgery; Smart neuro-rehabilitation; Bio-photonic sensing and imaging
Files:
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Collection:
Department of Robotics EngineeringRobotics Engineering Research Center1. Journal Articles
Department of Robotics EngineeringIntelligent Bio-OptoMechatronics Lab1. Journal Articles


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