Cited 1 time in webofscience Cited 2 time in scopus

ATM mediated-p53 signaling pathway forms a novel axis for senescence control

Title
ATM mediated-p53 signaling pathway forms a novel axis for senescence control
Authors
Hwang, Su YoungKuk, Myeong UkKim, Jae WonLee, Yun HaengLee, Young-SamChoy, Hyon EPark, Sang ChulPark, Joon Tae
DGIST Authors
Lee, Young-Sam
Issue Date
2020-11
Citation
Mitochondrion, 55, 54-63
Type
Article
Article Type
Article
Author Keywords
MitochondriaATM inhibitionP53Senescence alleviationMetabolic reprogrammer
Keywords
CELL-CYCLE ARRESTDNA-DAMAGEHUMAN FIBROBLASTSOXIDATIVE STRESSPIFITHRIN-ALPHAP53CANCERLIPOFUSCININHIBITORQUANTIFICATION
ISSN
1567-7249
Abstract
Previously, we uncovered a novel mechanism in which senescence is controlled by mitochondrial functional recovery upon Ataxia-telangiectasia mutated (ATM) inhibition. However, it remains elusive how ATM controls signaling pathways to achieve restorative effect. In this study, we performed microarray and found that p53 pathway was differentially expressed upon ATM inhibition. We found that ATM inhibition yields senescence amelioration through p53-dependent manner. The restorative effect was also afforded by direct p53 inhibition. Furthermore, mitochondrial metabolic reprogramming via p53 inhibition was a prerequisite for senescence amelioration. Taken together, our data indicated that p53 pathway functions as potential target for ATM-mediated senescence amelioration. © 2020 Elsevier B.V. and Mitochondria Research Society
URI
http://hdl.handle.net/20.500.11750/12665
DOI
10.1016/j.mito.2020.09.002
Publisher
Elsevier B.V.
Related Researcher
  • Author Lee, Young-Sam Senescence-Associated Mechanism Lab
  • Research Interests DNA replication and repair; Restoration of cellular senescence; Structural and functional relationship of proteins
Files:
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Collection:
Department of New BiologySenescence-Associated Mechanism Lab1. Journal Articles


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