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ATM mediated-p53 signaling pathway forms a novel axis for senescence control
- ATM mediated-p53 signaling pathway forms a novel axis for senescence control
- Hwang, Su Young; Kuk, Myeong Uk; Kim, Jae Won; Lee, Yun Haeng; Lee, Young-Sam; Choy, Hyon E; Park, Sang Chul; Park, Joon Tae
- DGIST Authors
- Lee, Young-Sam
- Issue Date
- Mitochondrion, 55, 54-63
- Article Type
- Author Keywords
- Mitochondria; ATM inhibition; P53; Senescence alleviation; Metabolic reprogrammer
- CELL-CYCLE ARREST; DNA-DAMAGE; HUMAN FIBROBLASTS; OXIDATIVE STRESS; PIFITHRIN-ALPHA; P53; CANCER; LIPOFUSCIN; INHIBITOR; QUANTIFICATION
- Previously, we uncovered a novel mechanism in which senescence is controlled by mitochondrial functional recovery upon Ataxia-telangiectasia mutated (ATM) inhibition. However, it remains elusive how ATM controls signaling pathways to achieve restorative effect. In this study, we performed microarray and found that p53 pathway was differentially expressed upon ATM inhibition. We found that ATM inhibition yields senescence amelioration through p53-dependent manner. The restorative effect was also afforded by direct p53 inhibition. Furthermore, mitochondrial metabolic reprogramming via p53 inhibition was a prerequisite for senescence amelioration. Taken together, our data indicated that p53 pathway functions as potential target for ATM-mediated senescence amelioration. © 2020 Elsevier B.V. and Mitochondria Research Society
- Elsevier B.V.
- Related Researcher
Senescence-Associated Mechanism Lab
DNA replication and repair; Restoration of cellular senescence; Structural and functional relationship of proteins
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- Department of New BiologySenescence-Associated Mechanism Lab1. Journal Articles
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